Research advances from the National Institutes of Health (NIH) Intramural Research Program (IRP) often make headlines. Read the news releases that describe our most recent findings:
Whether you’re shedding pounds with the help of effective new medicines, slimming down after weight loss surgery or cutting calories and adding exercise, there will come a day when the numbers on the scale stop going down, and you hit the dreaded weight loss plateau.
In a recent study, Kevin Hall, a researcher at the National Institutes of Health who specializes in measuring metabolism and weight change, looked at when weight loss typically stops depending on the method people were using todrop pounds. He broke down the plateau into mathematical models using data from high-quality clinical trials of different ways to lose weight to understand why people stop losing when they do. The study published Monday in the journal Obesity.
The NIH Clinical Center has discharged Ms. Nina Pham, the Texas nurse who was admitted on Thursday, October 16, with Ebola virus disease, after confirming that she is now free of the virus. It is critical to remember that people who have survived Ebola are not contagious and can no longer spread disease. We would not be releasing Ms. Pham if we were not completely confident in the knowledge that she has fully recovered, is virus free and poses no public health threat. The healthcare team at the NIH is pleased to have had the opportunity to provide care to Ms. Pham and guide her recovery. We extend our best wishes to her as she continues to regain her strength and return to normal life.
Human testing of a second investigational Ebola vaccine candidate is under way at the National Institutes of Health’s Clinical Center in Bethesda, Maryland.
Researchers at the National Institute of Allergy and Infectious Diseases (NIAID) are conducting the early phase trial to evaluate the vaccine, called VSV-ZEBOV, for safety and its ability to generate an immune system response in healthy adults who are given two intramuscular doses, called a prime-boost strategy. The Walter Reed Army Institute of Research (WRAIR) is simultaneously testing the vaccine candidate as a single dose at its Clinical Trials Center in Silver Spring, Maryland.
The NIH has received countless inquiries and expressions of support for Ms. Nina Pham, the Texas nurse who was admitted to the NIH Clinical Center Special Clinical Studies Unit on Thursday, October 16, with Ebola virus disease. The NIH Clinical Center staff has shared the general sentiments with her and Ms. Pham has expressed her gratitude for everyone’s concerns and well wishes. Ms. Pham’s clinical status has been upgraded from fair to good. No additional details are available at this time.
Mitochondrial oscillations have quietly bewildered scientists for more than 40 years. Now, a team of scientists at National Institutes of Health’s National Institute of Dental and Craniofacial Research (NIDCR) has imaged mitochondria for the first time oscillating in a live animal, in this case, the salivary glands of laboratory rats. The report, published online today in the journal Cell Reports, shows the oscillations occur spontaneously and often in the rodent cells, which leads the researchers to believe the oscillations almost surely also occur in human cells.
A drug being studied as a fast-acting mood-lifter restored pleasure-seeking behavior independent of — and ahead of — its other antidepressant effects, in a National Institutes of Health trial. Within 40 minutes after a single infusion of ketamine, treatment-resistant depressed bipolar disorder patients experienced a reversal of a key symptom — loss of interest in pleasurable activities — which lasted up to 14 days. Brain scans traced the agent’s action to boosted activity in areas at the front and deep in the right hemisphere of the brain.
Later today, the National Institutes of Health (NIH) Clinical Center expects to admit the first nurse who contracted the Ebola virus at Texas Health Presbyterian Hospital while providing patient care to the index patient who died of Ebola. The nurse is being admitted to the Special Clinical Studies Unit of the NIH Clinical Center at the request of Texas Health Presbyterian Hospital. She will receive state-of-the-art care in this high-level containment facility, which is one of a small number of such facilities in the United States.
A letter from Michael M. Gottesman, Deputy Director for Intramural Research
The NIH intramural program has placed its mark on another Nobel Prize. You likely heard last week that Eric Betzig of HHMI's Janelia Farm Research Campus will share the 2014 Nobel Prize in Chemistry "for the development of super-resolved fluorescence microscopy." Eric's key experiment came to life right here at the NIH, in the lab of Jennifer Lippincott-Schwartz.
NIH scientists find that restocking new cells in the brain’s center for smell maintains crucial circuitry
For decades, scientists thought that neurons in the brain were born only during the early development period and could not be replenished. More recently, however, they discovered cells with the ability to divide and turn into new neurons in specific brain regions. The function of these neuroprogenitor cells remains an intense area of research. Scientists at the National Institutes of Health (NIH) report that newly formed brain cells in the mouse olfactory system — the area that processes smells — play a critical role in maintaining proper connections.
National Institutes of Health grantee William E. Moerner of Stanford University in California shares the 2014 Nobel Prize in chemistry for his work on optical microscopy that has opened the understanding of molecules by allowing researchers to see how the molecules work close up. Dr. Moerner won the award jointly with Eric Betzig from Howard Hughes Medical Institute, Ashburn, Virginia, and Stefan W. Hell of the Max Planck Institute for Biophysical Chemistry, Gottingen, Heidelberg, Germany. NIH was also instrumental in the development of the first working model of Dr. Betzig’s microscope.
Earlier today the patient who was flown back to the United States from Sierra Leone and admitted to the NIH Clinical Center on September 28 for observation, following a high-risk exposure to Ebola virus infection, was discharged to his home.
