Kirk M. Druey, M.D.
Molecular Signal Transduction Section
4 Memorial Drive, Room 228B
Bethesda, MD 20814
The primary focus of our laboratory is to understand the signaling pathways evoked by G-protein-coupled receptors (GPCRs) and the role of the dysregulated GPCR signaling in the pathogenesis of asthma and allergic disease. Although therapeutic agents targeting GPCRs have long been used to treat asthma and allergies, much remains unknown regarding pathomechanisms associated with their downstream signaling pathways. Our goals are to identify specific genetic and molecular abnormalities involved in two distinct processes: 1) airway contraction and relaxation and 2) vascular permeability. Our studies of asthma utilize mouse models of allergen-induced airway inflammation, which have uncovered novel therapeutic targets for specific asthma endotypes. The second area of focus is a rare and highly unusual disorder, the Systemic Capillary Leak Syndrome. This disease is characterized by reversible episodes of hypovolemia, hypotensive shock, and anasarca, which are thought to be a result of transient endothelial hyper-permeability.
Dr. Druey obtained his M.D. from Rush Medical College in Chicago, Illinois. In 1992, following a residency in internal medicine at The New York Hospital/Cornell Medical Center, Dr. Druey became a postdoctoral fellow in the NIAID Laboratory of Immunoregulation. He joined the Laboratory of Allergic Diseases in 1997 to become chief of the Molecular Signal Transduction Section.
Balenga NA, Klichinsky M, Xie Z, Chan EC, Zhao M, Jude J, Laviolette M, Panettieri RA Jr, Druey KM. A fungal protease allergen provokes airway hyper-responsiveness in asthma. Nat Commun. 2015;6:6763.
Raza A, Xie Z, Chan EC, Chen WS, Scott LM, Robin Eisch A, Krementsov DN, Rosenberg HF, Parikh SM, Blankenhorn EP, Teuscher C, Druey KM. A natural mouse model reveals genetic determinants of systemic capillary leak syndrome (Clarkson disease). Commun Biol. 2019;2:398.
Balenga NA, Jester W, Jiang M, Panettieri RA Jr, Druey KM. Loss of regulator of G protein signaling 5 promotes airway hyperresponsiveness in the absence of allergic inflammation. J Allergy Clin Immunol. 2014;134(2):451-9.
Druey KM, Parikh SM. Idiopathic systemic capillary leak syndrome (Clarkson disease). J Allergy Clin Immunol. 2017;140(3):663-670.
Wong GS, Redes JL, Balenga N, McCullough M, Fuentes N, Gokhale A, Koziol-White C, Jude JA, Madigan LA, Chan EC, Jester WH, Biardel S, Flamand N, Panettieri RA Jr, Druey KM. RGS4 promotes allergen- and aspirin-associated airway hyperresponsiveness by inhibiting PGE2 biosynthesis. J Allergy Clin Immunol. 2020.
Related Scientific Focus Areas
Molecular Biology and Biochemistry
This page was last updated on July 29th, 2020