Jack Richard Bennink, Ph.D.

Senior Investigator

Cellular Biology and Viral Immunology Section


Building 33
Room 2E13C.4
33 North Drive
Bethesda, MD 20892



Research Topics

Virus infections within the human population impose a significant annual burden in morbidity, mortality, and economic loss. The immune system and viruses have evolved and continue to evolve in response to each other. The mission of the Viral Immunology Section is focused on extending our basic understanding of the interaction between the immune system and viruses.


Dr. Bennink obtained his Ph.D. from the University of Pennsylvania for the study of the specificity of virus immune effector T cells. He spent two years as a member of the Basel Institute for Immunology, followed by five years as assistant and associate professor at the Wistar Institute of Anatomy and Biology, before coming to the National Institute of Allergy and Infectious Diseases in 1987. His research focuses on influenza virus and antiviral immunity.

Selected Publications

  1. Magadán JG, Altman MO, Ince WL, Hickman HD, Stevens J, Chevalier A, Baker D, Wilson PC, Ahmed R, Bennink JR, Yewdell JW. Biogenesis of influenza a virus hemagglutinin cross-protective stem epitopes. PLoS Pathog. 2014;10(6):e1004204.

  2. Ince WL, Gueye-Mbaye A, Bennink JR, Yewdell JW. Reassortment complements spontaneous mutation in influenza A virus NP and M1 genes to accelerate adaptation to a new host. J Virol. 2013;87(8):4330-8.

  3. Brooke CB, Ince WL, Wrammert J, Ahmed R, Wilson PC, Bennink JR, Yewdell JW. Most influenza a virions fail to express at least one essential viral protein. J Virol. 2013;87(6):3155-62.

  4. Brooke CB, Ince WL, Wei J, Bennink JR, Yewdell JW. Influenza A virus nucleoprotein selectively decreases neuraminidase gene-segment packaging while enhancing viral fitness and transmissibility. Proc Natl Acad Sci U S A. 2014;111(47):16854-9.

  5. Frank GM, Angeletti D, Ince WL, Gibbs JS, Khurana S, Wheatley AK, Max EE, McDermott AB, Golding H, Stevens J, Bennink JR, Yewdell JW. A Simple Flow-Cytometric Method Measuring B Cell Surface Immunoglobulin Avidity Enables Characterization of Affinity Maturation to Influenza A Virus. MBio. 2015;6(4):e01156.

This page was last updated on August 2nd, 2017