Eliot Lawrence Gardner, Ph.D.

Senior Investigator

Chemical Biology Research Branch, Neuropsychopharmacology Section

NIDA

251 Bayview Boulevard
Suite 500
Baltimore, MD 21224

443-740-2516

egardner@mail.nih.gov

Research Topics

  • Basic brain mechanisms underlying drug addiction, craving, and relapse
  • Endocannabinoid brain mechanisms and addiction
  • Dopamine D3 receptor antagonists
  • Glutamatergic compounds, with emphasis on the metabotropic glutamate receptor
  • GABAergic agonists, with emphasis on the GABA-B receptor
  • Slow-onset long-acting dopamine transport inhibitors
  • Drugs acting on the endocannabinoid brain system
  • Research in all these areas is directed toward the development of effective anti-addiction, anti-craving, anti-relapse medications.

Selected Publications

  1. Vorel SR, Liu X, Hayes RJ, Spector JA, Gardner EL. Relapse to cocaine-seeking after hippocampal theta burst stimulation. Science. 2001;292(5519):1175-8.

  2. Vorel SR, Ashby CR Jr, Paul M, Liu X, Hayes R, Hagan JJ, Middlemiss DN, Stemp G, Gardner EL. Dopamine D3 receptor antagonism inhibits cocaine-seeking and cocaine-enhanced brain reward in rats. J Neurosci. 2002;22(21):9595-603.

  3. Hayes RJ, Vorel SR, Spector J, Liu X, Gardner EL. Electrical and chemical stimulation of the basolateral complex of the amygdala reinstates cocaine-seeking behavior in the rat. Psychopharmacology (Berl). 2003;168(1-2):75-83.

  4. Xi ZX, Gilbert JG, Peng XQ, Pak AC, Li X, Gardner EL. Cannabinoid CB1 receptor antagonist AM251 inhibits cocaine-primed relapse in rats: role of glutamate in the nucleus accumbens. J Neurosci. 2006;26(33):8531-6.

  5. Xi ZX, Spiller K, Pak AC, Gilbert J, Dillon C, Li X, Peng XQ, Gardner EL. Cannabinoid CB1 receptor antagonists attenuate cocaine's rewarding effects: experiments with self-administration and brain-stimulation reward in rats. Neuropsychopharmacology. 2008;33(7):1735-45.


This page was last updated on September 1st, 2017