Eliot L. Gardner, Ph.D.

Senior Investigator

Molecular Targets and Medications Discovery Branch, Neuropsychopharmacology Section

NIDA

Biomedical Research Center
251 Bayview Boulevard
Suite 200, Room 05A707
Baltimore, MD 21224

443-740-2516

egardner@mail.nih.gov

Research Topics

Research in the following areas is directed toward the development of effective anti-addiction, anti-craving, anti-relapse medications:
  • Basic brain mechanisms underlying drug addiction, craving, and relapse
  • Endocannabinoid brain mechanisms and addiction
  • Dopamine D3 receptor antagonists
  • Glutamatergic compounds, with emphasis on the metabotropic glutamate receptor
  • GABAergic agonists, with emphasis on the GABA-B receptor
  • Slow-onset long-acting dopamine transport inhibitors
  • Drugs acting on the endocannabinoid brain system

Selected Publications

  1. Vorel SR, Liu X, Hayes RJ, Spector JA, Gardner EL. Relapse to cocaine-seeking after hippocampal theta burst stimulation. Science. 2001;292(5519):1175-8.

  2. Vorel SR, Ashby CR Jr, Paul M, Liu X, Hayes R, Hagan JJ, Middlemiss DN, Stemp G, Gardner EL. Dopamine D3 receptor antagonism inhibits cocaine-seeking and cocaine-enhanced brain reward in rats. J Neurosci. 2002;22(21):9595-603.

  3. Xi ZX, Spiller K, Pak AC, Gilbert J, Dillon C, Li X, Peng XQ, Gardner EL. Cannabinoid CB1 receptor antagonists attenuate cocaine's rewarding effects: experiments with self-administration and brain-stimulation reward in rats. Neuropsychopharmacology. 2008;33(7):1735-45.

  4. Zhang HY, Gao M, Liu QR, Bi GH, Li X, Yang HJ, Gardner EL, Wu J, Xi ZX. Cannabinoid CB2 receptors modulate midbrain dopamine neuronal activity and dopamine-related behavior in mice. Proc Natl Acad Sci U S A. 2014;111(46):E5007-15.

  5. Xi ZX, Muldoon P, Wang XF, Bi GH, Damaj MI, Lichtman AH, Pertwee RG, Gardner EL. Δ<sup>8</sup> -Tetrahydrocannabivarin has potent anti-nicotine effects in several rodent models of nicotine dependence. Br J Pharmacol. 2019;176(24):4773-4784.


This page was last updated on November 2nd, 2018