Eliot Lawrence Gardner, Ph.D.
Chemical Biology Research Branch, Neuropsychopharmacology Section
251 Bayview Boulevard
Baltimore, MD 21224
- Basic brain mechanisms underlying drug addiction, craving, and relapse
- Endocannabinoid brain mechanisms and addiction
- Dopamine D3 receptor antagonists
- Glutamatergic compounds, with emphasis on the metabotropic glutamate receptor
- GABAergic agonists, with emphasis on the GABA-B receptor
- Slow-onset long-acting dopamine transport inhibitors
- Drugs acting on the endocannabinoid brain system
- Research in all these areas is directed toward the development of effective anti-addiction, anti-craving, anti-relapse medications.
Vorel SR, Liu X, Hayes RJ, Spector JA, Gardner EL. Relapse to cocaine-seeking after hippocampal theta burst stimulation. Science. 2001;292(5519):1175-8.
Vorel SR, Ashby CR Jr, Paul M, Liu X, Hayes R, Hagan JJ, Middlemiss DN, Stemp G, Gardner EL. Dopamine D3 receptor antagonism inhibits cocaine-seeking and cocaine-enhanced brain reward in rats. J Neurosci. 2002;22(21):9595-603.
Hayes RJ, Vorel SR, Spector J, Liu X, Gardner EL. Electrical and chemical stimulation of the basolateral complex of the amygdala reinstates cocaine-seeking behavior in the rat. Psychopharmacology (Berl). 2003;168(1-2):75-83.
Xi ZX, Gilbert JG, Peng XQ, Pak AC, Li X, Gardner EL. Cannabinoid CB1 receptor antagonist AM251 inhibits cocaine-primed relapse in rats: role of glutamate in the nucleus accumbens. J Neurosci. 2006;26(33):8531-6.
Xi ZX, Spiller K, Pak AC, Gilbert J, Dillon C, Li X, Peng XQ, Gardner EL. Cannabinoid CB1 receptor antagonists attenuate cocaine's rewarding effects: experiments with self-administration and brain-stimulation reward in rats. Neuropsychopharmacology. 2008;33(7):1735-45.
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This page was last updated on September 1st, 2017