Research advances from the National Institutes of Health (NIH) Intramural Research Program (IRP) often make headlines. Read the news releases that describe our most recent findings:
BETHESDA, Md. (AP) — Sam Srisatta, a 20-year-old Florida college student, spent a month living inside a government hospital here last fall, playing video games and allowing scientists to document every morsel of food that went into his mouth.
From big bowls of salad to platters of meatballs and spaghetti sauce, Srisatta noshed his way through a nutrition study aimed at understanding the health effects of ultraprocessed foods, the controversial fare that now accounts for more than 70% of the U.S. food supply. He allowed The Associated Press to tag along for a day.
“Today my lunch was chicken nuggets, some chips, some ketchup,” said Srisatta, one of three dozen participants paid $5,000 each to devote 28 days of their lives to science. “It was pretty fulfilling.”
Examining exactly what made those nuggets so satisfying is the goal of the widely anticipated research led by National Institutes of Health nutrition researcher Kevin Hall.
“What we hope to do is figure out what those mechanisms are so that we can better understand that process,” Hall said.
President Obama has chosen 20 NIH scientists for this year’s Presidential Early Career Award for Scientists and Engineers (PECASE), the highest honor bestowed by the U.S. government to outstanding scientists and engineers beginning their independent careers. Of the 20 NIH honorees, 17 are new investigators working at institutions around the nation. The others have positions in the NIH Intramural Programs.
In a study of African-American men, researchers from the National Institutes of Health found that boys who grew up in two-parent homes were less likely to have high blood pressure as adults compared to those raised by a single parent.
Study calls for a shift in understanding of how complex cell types evolved
In a study that compares the genomes of aquatic life forms, researchers have found evidence to shuffle the branches of the tree of life. For more than a century, scientists thought that complex cell types, like neurons and muscles, evolved only once, after simple animals that lack these cell types branched from the rest of animals on the evolutionary tree. A team of researchers from the National Human Genome Research Institute (NHGRI), part of the National Institutes of Health, has provided new evidence from the genomic study of a ctenophore species — a comb jelly — that challenges this long-held view.
Smoking tobacco or marijuana, taking prescription painkillers, or using illegal drugs during pregnancy is associated with double or even triple the risk of stillbirth, according to research funded by the National Institutes of Health.
NIH scientists film early concussion damage and describe brain’s response to injury
There is more than meets the eye following even a mild traumatic brain injury. While the brain may appear to be intact, new findings reported in Nature suggest that the brain’s protective coverings may feel the brunt of the impact.
Using a newly developed mouse trauma model, senior author Dorian McGavern, Ph.D., scientist at the National Institute of Neurological Disorders and Stroke (NINDS), part of the National Institutes of Health, watched specific cells mount an immune response to the injury and try to prevent more widespread damage. Notably, additional findings suggest a similar immune response may occur in patients with mild head injury. (Video)
Mutation found by NIH, French team may allow for early identification of patients
Many cases of a rare disorder of the adrenal glands appear to result from two copies of a mutant gene, according to a research team made up of scientists in France and at the U.S. National Institutes of Health. The adrenal disorder, Corticotropin-independent macronodular adrenal hyperplasia External Web Site Policy, results in the formation of numerous tumors in the adrenal glands located on top of the kidneys, and which produce hormones that help the body respond to stress. The condition is one of many causes of Cushing’s syndrome, a group of symptoms resulting from an excess of cortisol, a stress hormone. Untreated, Cushing syndrome can result in high blood pressure, heart disease, bone loss, diabetes, and other health problems.
NIH study sheds light on treatment of related disorders
Scientists at the National Institutes of Health have used RNA interference (RNAi) technology to reveal dozens of genes which may represent new therapeutic targets for treating Parkinson’s disease. The findings also may be relevant to several diseases caused by damage to mitochondria, the biological power plants found in cells throughout the body.
An intact population of microorganisms that derive food and benefit from other organisms living in the intestine is required for optimal response to cancer therapy, according to a mouse study by scientists at the National Cancer Institute (NCI), part of the National Institutes of Health, and their collaborators.
Researchers have identified a genomic variant strongly associated with sensitivity to the sun, brown hair, blue eyes – and freckles. In the study of Icelanders the researchers uncovered an intricate pathway involving the interspersed DNA sequence, or non-coding region, of a gene that is among a few dozen that are associated with human pigmentation traits.
Adult patients with a type of cancer known as Burkitt lymphoma had excellent long-term survival rates — upwards of 90 percent — following treatment with low-intensity chemotherapy regimens, according to a new clinical trial finding. Standard treatment for Burkitt lymphoma involves high-dose chemotherapy, which has a high rate of toxicity, including death, and cures only 60 percent of adult patients. This trial was conducted by researchers at the National Cancer Institute (NCI), part of the National Institutes of Health, and appeared Nov. 14, 2013, in the New England Journal of Medicine.
