Twins grow more slowly in early pregnancy than previously thought

Monday, April 7, 2025

NIH findings could lead to more efficient monitoring of twin pregnancies.

Twins—smaller at birth, on average, than singletons—start out smaller in pregnancy than was previously known, according to a study by researchers at the National Institutes of Health (NIH). The ultrasound study revealed that twins have less fat tissue and less muscle mass than singletons beginning at 15 weeks of pregnancy. If results are confirmed by additional research, the findings could provide information to guide physicians in monitoring and managing twin pregnancies.

Researchers analyzed data from previous ultrasound studies of fetal development in the uterus. Included in the analysis were 3D ultrasound scans of 2,604 singleton pregnancies and 315 twins. All twin pairs had individual placentas. Twin pairs who shared a placenta were not included in the analysis.

Beginning at 15 weeks, thigh volumes were significantly smaller for twins than singletons. Twins had smaller fat and lean thigh volumes than singletons. They also had a lower thigh fat to lean ratio than singletons, having proportionately 2.7 to 4.2 percent less fat from 15 to 37 weeks. Previous studies of twin growth in the womb involved 2D ultrasound scans and had documented decreased twin growth relative to singletons only in the early third trimester (28 to 40 weeks).

The study was conducted by Jessica Gleason, Ph.D., and Katherine Grantz, M.D., of NIH’s Eunice Kennedy Shriver National Institute of Child Health and Human Development, and their colleagues. It appears in JAMA Pediatrics.