Katherine Laughon Grantz, M.S.,M.D.

Senior Investigator

Epidemiology Branch

NICHD/DIPHR

6710 Rockledge Dr. Wing B 3124
20892

301-435-6935

katherine.grantz@nih.gov

Research Topics

Dr. Grantz' overarching research goal is to provide evidence for improved clinical management of pregnancy complications, including fetal growth and labor and delivery management with a focus on when to deliver a high-risk pregnancy. Fetal growth is one of the earliest indicators of health. However, classifying "optimal" growth and distinguishing from suboptimal to identify individuals for clinical intervention remains a challenge. Dr. Grantz's research addresses this important data gap using several approaches, including generating fetal growth standards for application in clinical practice, investigating the role of fetal growth velocity, and examining the benefits of customized and individualized fetal growth references. She is expanding on this work as the PI of the NICHD Fetal 3D Study to investigate fetal body composition, including lean and fat tissue, and visceral volumes that may be important predictors of birth weight, neonatal anthropometrics and morbidity that may not be otherwise apparent until birth.

She also is leading work in the Consortium on Safe Labor (CSL) study to inform national and international clinical guidelines. Building on findings from observational data, Dr. Grantz is leading a randomized trial with a response adaptive randomization to determine the optimal time to initiate delivery for uncontrolled GDM-complicated pregnancies, in The Study of Pregnancy And Neonatal health (SPAN). Her future research continues the goal of providing evidence to inform clinical practice, ultimately to decrease in perinatal morbidity and mortality on a population level.

Biography

Katherine Laughon Grantz, M.D., M.S. is a Senior Investigator in the Epidemiology Branch, DiPHR, DIR, NICHD, NIH. She received her M.D. at Virginia Commonwealth University School of Medicine and completed a residency in Obstetrics and Gynecology at the University of North Carolina, Chapel Hill. She completed her fellowship in Maternal-Fetal Medicine at the University of Pittsburgh Magee-Womens Hospital and received her Master of Science in Clinical Research through the NIH Clinical Research Training Program at the University of Pittsburgh, Pennsylvania. She is a doubly board-certified Obstetrician and Gynecologist with specialization in Maternal-Fetal Medicine.

Selected Publications

  1. Grantz KL, Grewal J, Kim S, Grobman WA, Newman RB, Owen J, Sciscione A, Skupski D, Chien EK, Wing DA, Wapner RJ, Ranzini AC, Nageotte MP, Craigo S, Hinkle SN, D'Alton ME, He D, Tekola-Ayele F, Hediger ML, Buck Louis GM, Zhang C, Albert PS. Unified standard for fetal growth: the Eunice Kennedy Shriver National Institute of Child Health and Human Development Fetal Growth Studies. Am J Obstet Gynecol. 2022;226(4):576-587.e2.
  2. Grantz KL, Grewal J, Albert PS, Wapner R, D'Alton ME, Sciscione A, Grobman WA, Wing DA, Owen J, Newman RB, Chien EK, Gore-Langton RE, Kim S, Zhang C, Buck Louis GM, Hediger ML. Dichorionic twin trajectories: the NICHD Fetal Growth Studies. Am J Obstet Gynecol. 2016;215(2):221.e1-221.e16.
  3. Grantz KL, Sundaram R, Ma L, Hinkle S, Berghella V, Hoffman MK, Reddy UM. Reassessing the Duration of the Second Stage of Labor in Relation to Maternal and Neonatal Morbidity. Obstet Gynecol. 2018;131(2):345-353.
  4. Laughon SK, Branch DW, Beaver J, Zhang J. Changes in labor patterns over 50 years. Am J Obstet Gynecol. 2012;206(5):419.e1-9.

Related Scientific Focus Areas

This page was last updated on Thursday, January 26, 2023