Harnessing Mechanistic Insights into microRNA Function for Cancer Therapy


Dr. Shuo Gu

NIH Building 1, Wilson Hall; and NIH Videocast

The April lecture in the NIH Director's Seminar Series will be presented by IRP senior investigator Shuo Gu, Ph.D.

As a class of small non-coding RNAs, microRNAs (miRNAs) function as master gene regulators. Dr. Guo's laboratory studies how miRNAs themselves are regulated and their applications in cancer treatment. Despite the success of using miRNAs including their isoforms (isomiRs) as disease biomarkers, development of miRNA-based cancer treatments was somewhat lagging behind mainly due to the difficulty in identifying tumor-driver miRNA variations. In this talk, Dr. Guo will discuss his lab's endeavor in addressing this challenge by investigating the mechanisms of miRNA biogenesis and function. He will also talk about his team's recent endeavor in characterizing genetic variants of miRNA biogenesis enzymes associated with certain pediatric cancers. His lab's findings will provide new targets for treating cancers with RNA-based therapeutics.

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This page was last updated on Monday, March 18, 2024