Yousuke Takahama, Ph.D.

Senior Investigator

Experimental Immunology Branch


Building 10, Room 4B10
Bethesda, MD 20892


Research Topics

The questions we would like to address in the next few years include how diverse microenvironments are formed in the thymus. How the thymic microenvironment contributes to the establishment of self-tolerance in T cells is another important question. We also would like to study the mechanisms involved in how developing T cells localize multiple thymic microenvironments for T cell repertoire formation and how positive selection in the thymic microenvironment fine-tunes antigen responsiveness in T cells.


Yousuke Takahama received his Ph.D. from Osaka University Graduate School of Medicine in Japan. He was a Visiting Fellow and Visiting Associate in the Experimental Immunology Branch, National Cancer Institute, where he studied thymocyte development and selection. He then started working on the biology of thymic microenvironments at Syntex Institute of Immunology and the University of Tsukuba in Japan. In 1999, he was appointed a Professor of Experimental Immunology, University of Tokushima. In 2018, he moved back to the United States to establish a new laboratory as a Senior Investigator in Experimental Immunology Branch, National Cancer Institute. He is a founding organizer of the Global Thymus Network. His main interests are the development and function of the thymus and thymic epithelial cells, especially with regard to the repertoire selection of T lymphocytes.

This page was last updated on February 4th, 2019