Yogen Kanthi, M.D.
Lasker Clinical Research Scholar
Vascular Thrombosis and Inflammation
As a cardiologist and clinical vascular medicine specialist, Dr. Kanthi’s laboratory aims to understand how inflammation and coagulation contribute to vascular disease. We are interested in developing a deeper understanding of how innate immune circuits and communicate with coagulation and the vessel wall to license or restrict thrombosis.
Dr. Kanthi joined the NIH to build a translational vascular medicine research program. His team has studied the role of inlammasome activation and purine signaling in venous thrombosis (JCI, ATVB, Nature Communications). The Laboratory of Vascular Thrombosis and Inflammation (LVTI)has made seminal discoveries in COVID-19 pathology, being the first to identify neutrophil extracellular traps in patients with COVID-19 (JCI Insight), a new calprotectin biomarker for COVID-19 severity (J Leuk Biol), and the discovery of prothrombotic autoAntibodies in patients with COVID-19 (Science Translational Medicine).
With expertise in thrombo-inflammation and vascular biology, Dr. Kanthi launched a clinical trial at the University of Michigan (NCT04399179) to test dipyridamole, a repurposed FDA-approved drug in patients with COVID-19.
The goal of the LVTI is to identify the molecular and cellular processes that lead to vascular thrombo-inflammation and design better therapeutic approaches for patients with vascular disease.
Dr. Kanthi completed his residency training Internal Medicine at University Hospitals Case Western Reserve University, and served as the Department's Chief Medical Resident in 2008, after which he joined the University of Michigan for a Cardiovascular Medicine and a Vascular Medicine fellowship. Dr. Kanthi did an NIH-funded post-doctoral research fellowship with Dr. David J. Pinsky in vascular biology focused on mechanotransduction and atherosclerosis in arteries.
Following his research fellowship, he did a year of dedicated clinical vascular medicine training during which he recognized the need for advancement in treatments for patients with venous thrombosis (DVT) and peripheral artery disease (PAD). Dr. Kanthi joined the faculty of the University of Michigan in 2014, and has made DVT and PAD the focus of his translational research laboratory. As a faculty member, he has been awarded a Young Physician Scientist Award by the American Society of Clinical Investigation. His academic interests focus on understanding the pathological processes that lead to innate immune activation in venous thrombosis, vein graft disease, and mechanotransduction in the vessel wall. Dr. Kanthi is board certified in Cardiovascular Medicine.
- Billi AC, Wasikowski R, Ma F, Yalavarthi S, Hoy CK, Zuo Y, Patrick MT, Shah N, Parker C, Aaronson C, Harbaugh A, Lucido MF, Shedden K, Rao K, IglayReger HB, Burant CF, Kahlenberg JM, Tsoi LC, Gudjonsson JE, Knight JS, Kanthi Y. Key patient demographics shape innate immune topography in noncritical hypoxic COVID-19 pneumonia. JCI Insight. 2023;8(16).
- Zuo Y, Estes SK, Ali RA, Gandhi AA, Yalavarthi S, Shi H, Sule G, Gockman K, Madison JA, Zuo M, Yadav V, Wang J, Woodard W, Lezak SP, Lugogo NL, Smith SA, Morrissey JH, Kanthi Y, Knight JS. Prothrombotic autoantibodies in serum from patients hospitalized with COVID-19. Sci Transl Med. 2020;12(570).
- Shi H, Zuo Y, Navaz S, Harbaugh A, Hoy CK, Gandhi AA, Sule G, Yalavarthi S, Gockman K, Madison JA, Wang J, Zuo M, Shi Y, Maile MD, Knight JS, Kanthi Y. Endothelial Cell-Activating Antibodies in COVID-19. Arthritis Rheumatol. 2022;74(7):1132-1138.
- Shi H, Zuo Y, Yalavarthi S, Gockman K, Zuo M, Madison JA, Blair C, Woodward W, Lezak SP, Lugogo NL, Woods RJ, Lood C, Knight JS, Kanthi Y. Neutrophil calprotectin identifies severe pulmonary disease in COVID-19. J Leukoc Biol. 2021;109(1):67-72.
- Zuo Y, Yalavarthi S, Shi H, Gockman K, Zuo M, Madison JA, Blair C, Weber A, Barnes BJ, Egeblad M, Woods RJ, Kanthi Y, Knight JS. Neutrophil extracellular traps in COVID-19. JCI Insight. 2020;5(11).
Related Scientific Focus Areas
Molecular Biology and Biochemistry
This page was last updated on Wednesday, September 13, 2023