Yinling Hu, Ph.D.

Senior Investigator

Cancer Innovation Laboratory


Building 567, Room 252
Frederick, MD 21702-1201



Research Topics

The research interests of the Inflammation and Tumorigenesis Section are to understand the physiological activities of IKKα in skin tumorigenesis and inflammation and to reveal the mechanisms by which IKKα regulates these functions using genetic animal models, including IKKα conditional knockout, IKKα kinase inactive knockin and IKKα transgenic mice, as well as molecular biology approaches.


Dr. Hu received her undergraduate degree from the Chinese Academy of Medical Science, Beijing, China and received her Ph.D. from the University of Melbourne, Australia. She was a postdoctoral fellow in Michael Karin's laboratory, University of California at San Diego from 1996 to 2001. Dr. Hu established her own laboratory in 2001 when she became an assistant professor at the Science Park Research Division, MD Anderson Cancer Center. In 2008 she became a principal investigator in the Cancer and Inflammation Program and was awarded tenure in 2016.

Selected Publications

  1. Zhu F, Willette-Brown J, Song NY, Lomada D, Song Y, Xue L, Gray Z, Zhao Z, Davis SR, Sun Z, Zhang P, Wu X, Zhan Q, Richie ER, Hu Y. Autoreactive T Cells and Chronic Fungal Infection Drive Esophageal Carcinogenesis. Cell Host Microbe. 2017;21(4):478-493.e7.
  2. Martin BN, Wang C, Willette-Brown J, Herjan T, Gulen MF, Zhou H, Bulek K, Franchi L, Sato T, Alnemri ES, Narla G, Zhong XP, Thomas J, Klinman D, Fitzgerald KA, Karin M, Nuñez G, Dubyak G, Hu Y, Li X. IKKα negatively regulates ASC-dependent inflammasome activation. Nat Commun. 2014;5:4977.
  3. Xiao Z, Jiang Q, Willette-Brown J, Xi S, Zhu F, Burkett S, Back T, Song NY, Datla M, Sun Z, Goldszmid R, Lin F, Cohoon T, Pike K, Wu X, Schrump DS, Wong KK, Young HA, Trinchieri G, Wiltrout RH, Hu Y. The pivotal role of IKKα in the development of spontaneous lung squamous cell carcinomas. Cancer Cell. 2013;23(4):527-40.
  4. Balkhi MY, Willette-Brown J, Zhu F, Chen Z, Liu S, Guttridge DC, Karin M, Hu Y. IKKα-mediated signaling circuitry regulates early B lymphopoiesis during hematopoiesis. Blood. 2012;119(23):5467-77.
  5. Liu B, Xia X, Zhu F, Park E, Carbajal S, Kiguchi K, DiGiovanni J, Fischer SM, Hu Y. IKKalpha is required to maintain skin homeostasis and prevent skin cancer. Cancer Cell. 2008;14(3):212-25.

Related Scientific Focus Areas

This page was last updated on Tuesday, December 5, 2023