Yihong Yang, Ph.D.

Senior Investigator

Neuroimaging Research Branch, Magnetic Resonance Imaging and Spectroscopy Section


Biomedical Research Center
251 Bayview Boulevard
Suite 200, Room 7A709
Baltimore, MD 21224



Research Topics

Dr. Yang’s research has been conducted in the following aspects:
  1. To develop advanced neuroimaging technology and understand the neurophysiological basis of neuroimaging measures;
  2. To identify system-level biomarkers of substance addiction using advanced neuroimaging technology;
  3. To investigate neuroadaptations in translational animal models of psychiatric and neurological disorders.


Dr. Yang received his Ph.D. degree in Biophysics from the University of Illinois at Urbana-Champaign in 1995. His training was on the magnetic resonance imaging and spectroscopy and their applications in biology and medicine. He was a Postdoctoral Fellow in the Laboratory of Diagnostic Radiology Research, Clinical Center, National Institutes of Health from 1995 to 1998. He was then an Assistant Professor at the Department of Psychiatry, Weill Medical College of Cornell University from 1998 to 2002. He became an Investigator and Chief of MRI Physics at the National Institute on Drug Abuse in 2002, and then a Senior Investigator and Chief of MR Imaging and Spectroscopy Section in 2007.

Selected Publications

  1. Fredriksson I, Tsai PJ, Shekara A, Duan Y, Applebey SV, Lu H, Bossert JM, Shaham Y, Yang Y. Orbitofrontal cortex and dorsal striatum functional connectivity predicts incubation of opioid craving after voluntary abstinence. Proc Natl Acad Sci U S A. 2021;118(43).
  2. Zhai T, Salmeron BJ, Gu H, Adinoff B, Stein EA, Yang Y. Functional connectivity of dorsolateral prefrontal cortex predicts cocaine relapse: implications for neuromodulation treatment. Brain Commun. 2021;3(2):fcab120.
  3. Tsai PJ, Keeley RJ, Carmack SA, Vendruscolo JCM, Lu H, Gu H, Vendruscolo LF, Koob GF, Lin CP, Stein EA, Yang Y. Converging Structural and Functional Evidence for a Rat Salience Network. Biol Psychiatry. 2020;88(11):867-878.
  4. Gu H, Schulz KP, Fan J, Yang Y. Temporal Dynamics of Functional Brain States Underlie Cognitive Performance. Cereb Cortex. 2021;31(4):2125-2138.
  5. Hu Y, Salmeron BJ, Krasnova IN, Gu H, Lu H, Bonci A, Cadet JL, Stein EA, Yang Y. Compulsive drug use is associated with imbalance of orbitofrontal- and prelimbic-striatal circuits in punishment-resistant individuals. Proc Natl Acad Sci U S A. 2019;116(18):9066-9071.

Related Scientific Focus Areas

This page was last updated on Friday, November 2, 2018