Yie Liu, Ph.D.
Laboratory of Molecular Gerontology
251 Bayview Boulevard
Baltimore, MD 21224
A number of age-related pathologies are associated with abnormal telomere length, suggesting that telomere defects may play a role in aging. It is believed that owing to its repetitive sequence, telomere can form unusual secondary structures (e.g., G-quadruplex and a lariat-like T-loop configuration), both of which impact telomere maintenance. We investigate the hypothesis that inadequate DNA structural resolution would impact telomere maintenance and function. Using a combination of molecular, genetic, and biochemical approaches, we are interested in probing (1) the key genes that modulate unique DNA secondary structures at telomeres; and (2) the contributions of DNA resolution deficiency to telomere defects in aging and premature aging syndromes. These studies will enhance our understanding of how DNA resolution deficiencies affect telomere maintenance and thus aging and related human diseases.
Dr. Yie Liu received her Ph.D. at Karolinska Institute, Sweden in 1995 and then joined the University of Toronto as a postdoctoral fellow of the National Cancer Institute of Canada. She became a principal investigator at NIA since 2006.
Shi J, Yang XR, Ballew B, Rotunno M, Calista D, Fargnoli MC, Ghiorzo P, Bressac-de Paillerets B, Nagore E, Avril MF, Caporaso NE, McMaster ML, Cullen M, Wang Z, Zhang X, NCI DCEG Cancer Sequencing Working Group., NCI DCEG Cancer Genomics Research Laboratory., French Familial Melanoma Study Group., Bruno W, Pastorino L, Queirolo P, Banuls-Roca J, Garcia-Casado Z, Vaysse A, Mohamdi H, Riazalhosseini Y, Foglio M, Jouenne F, Hua X, Hyland PL, Yin J, Vallabhaneni H, Chai W, Minghetti P, Pellegrini C, Ravichandran S, Eggermont A, Lathrop M, Peris K, Scarra GB, Landi G, Savage SA, Sampson JN, He J, Yeager M, Goldin LR, Demenais F, Chanock SJ, Tucker MA, Goldstein AM, Liu Y, Landi MT. Rare missense variants in POT1 predispose to familial cutaneous malignant melanoma. Nat Genet. 2014;46(5):482-6.
Wan B, Yin J, Horvath K, Sarkar J, Chen Y, Wu J, Wan K, Lu J, Gu P, Yu EY, Lue NF, Chang S, Liu Y, Lei M. SLX4 assembles a telomere maintenance toolkit by bridging multiple endonucleases with telomeres. Cell Rep. 2013;4(5):861-9.
Sarkar J, Wan B, Yin J, Vallabhaneni H, Horvath K, Kulikowicz T, Bohr VA, Zhang Y, Lei M, Liu Y. SLX4 contributes to telomere preservation and regulated processing of telomeric joint molecule intermediates. Nucleic Acids Res. 2015;43(12):5912-23.
Lu J, Liu Y. Deletion of Ogg1 DNA glycosylase results in telomere base damage and length alteration in yeast. EMBO J. 2010;29(2):398-409.
Kim J, Sun C, Tran AD, Chin PJ, Ruiz PD, Wang K, Gibbons RJ, Gamble MJ, Liu Y, Oberdoerffer P. The macroH2A1.2 histone variant links ATRX loss to alternative telomere lengthening. Nat Struct Mol Biol. 2019;26(3):213-219.
Related Scientific Focus Areas
Genetics and Genomics
This page was last updated on August 22nd, 2019