Yaron Rotman, M.D., M.Sc.
Clinical Research Section - Liver and Energy Metabolism Unit, Liver Diseases Branch
Building 10, Room 9C434
10 Center Drive
Bethesda, MD 20814
My ultimate goal is to increase understanding of the pathophysiology of fatty liver disease to allow for development of better treatment options.
Non-alcoholic fatty liver disease (NAFLD) is the most common liver disorder in the western world and is closely associated with metabolic syndrome, insulin resistance, and obesity. My main interest is in understanding the disease pathophysiology and through it, normal liver physiology. My studies focus on understanding the genetic aspects of fatty liver disease, its pathogenesis, the mechanisms of action of various treatment options, and the prediction of response to treatment.
Applying our Research
Non-alcoholic fatty liver disease is an extremely common disorder (affecting 30 percent of Americans) but currently has no approved therapy. Better understanding of the mechanisms of disease may allow for identification of druggable targets, better selection of patients for treatment, and early prediction of treatment response, with the overall effect of preventing death and suffering associated with the disease.
Need for Further Study
We need a better understanding of the mechanisms that cause some individuals to accumulate fat in the liver during caloric excess, while others are protected. Similarly, it is unclear why some individuals will develop liver injury and progressive disease after accumulating fat in their liver, while others maintain a relatively benign course. Finally, better treatment options are needed.
- Clinical Research Fellow, Liver Diseases Branch, NIDDK, 2006-2009
- Gastroenterology and Hepatology Fellowship, Rabin Medical Center, 2003-2006
- Internal Medicine Residency, Rabin Medical Center, 2000-2003
- M.D., Hebrew University Hadassah Medical School, 2000
- M.Sc., Hebrew University Hadassah Medical School, 2000
Rotman Y, Noureddin M, Feld JJ, Guedj J, Witthaus M, Han H, Park YJ, Park SH, Heller T, Ghany MG, Doo E, Koh C, Abdalla A, Gara N, Sarkar S, Thomas E, Ahlenstiel G, Edlich B, Titerence R, Hogdal L, Rehermann B, Dahari H, Perelson AS, Hoofnagle JH, Liang TJ. Effect of ribavirin on viral kinetics and liver gene expression in chronic hepatitis C. Gut. 2014;63(1):161-9.
Takyar V, Nath A, Beri A, Gharib AM, Rotman Y. How healthy are the "Healthy volunteers"? Penetrance of NAFLD in the biomedical research volunteer pool. Hepatology. 2017.
Han H, Noureddin M, Witthaus M, Park YJ, Hoofnagle JH, Liang TJ, Rotman Y. Temperature rise after peginterferon alfa-2a injection in patients with chronic hepatitis C is associated with virological response and is modulated by IL28B genotype. J Hepatol. 2013;59(5):957-63.
Rotman Y, Sanyal AJ. Current and upcoming pharmacotherapy for non-alcoholic fatty liver disease. Gut. 2017;66(1):180-190.
Rotman Y, Koh C, Zmuda JM, Kleiner DE, Liang TJ, NASH CRN.. The association of genetic variability in patatin-like phospholipase domain-containing protein 3 (PNPLA3) with histological severity of nonalcoholic fatty liver disease. Hepatology. 2010;52(3):894-903.
Related Scientific Focus Areas
Genetics and Genomics
Molecular Biology and Biochemistry
This page was last updated on March 27th, 2017