Wei Yang, Ph.D.
NIH Distinguished Investigator
Mechanism of DNA Repair, Replication, and Recombination Section, Laboratory of Molecular Biology
Building 5, Room B107
5 Memorial Dr
Bethesda, MD 20814
+1 301 402 4645
My group studies DNA recombination, repair, and replication. In particular, we are interested in V(D)J recombination, mismatch repair, nucleotide excision repair, and translesion DNA synthesis. We use X-ray crystallography, cryoEM, molecular biology, and various biochemical and biophysical approaches to find out the molecular mechanisms underpinning these biological processes. In recent years, we have discovered that DNA synthesis and RNA degradation reactions are propelled by cation trafficking and require transiently bound Mg²⁺ and K⁺ ions that are absent in the static structures of substrate- or product-enzyme complexes.
- American Academy of Arts and Sciences, 2015
- National Academy of Sciences, 2013
- Ph.D., Columbia University, 1991
- M.A., Columbia University, 1985
- B.A., State University of New York at Stony Brook, 1985
- B.A., State University of New York at Stony Brook, 1983
Gao Y, Yang W. Capture of a third Mg²⁺ is essential for catalyzing DNA synthesis. Science. 2016;352(6291):1334-7.
Nakamura T, Zhao Y, Yamagata Y, Hua YJ, Yang W. Watching DNA polymerase η make a phosphodiester bond. Nature. 2012;487(7406):196-201.
Gupta S, Gellert M, Yang W. Mechanism of mismatch recognition revealed by human MutSβ bound to unpaired DNA loops. Nat Struct Mol Biol. 2011;19(1):72-8.
Zhao Y, Biertümpfel C, Gregory MT, Hua YJ, Hanaoka F, Yang W. Structural basis of human DNA polymerase η-mediated chemoresistance to cisplatin. Proc Natl Acad Sci U S A. 2012;109(19):7269-74.
Lee YS, Gao Y, Yang W. How a homolog of high-fidelity replicases conducts mutagenic DNA synthesis. Nat Struct Mol Biol. 2015;22(4):298-303.
Related Scientific Focus Areas
Microbiology and Infectious Diseases
Molecular Biology and Biochemistry
This page was last updated on January 15th, 2019