Wei Yang, Ph.D.
NIH Distinguished Investigator
Mechanism of DNA Repair, Replication, and Recombination Section, Laboratory of Molecular Biology
NIDDK
Research Topics
Current Research
My group is interested in studying DNA recombination, repair, and replication. In particular, we are interested in V(D)J recombination, mismatch repair, nucleotide excision repair, and translesion DNA synthesis. We use X-ray crystallography, molecular biology, and various biochemical and biophysical approaches to find out the molecular mechanisms in these biological processes.
Biography
- Ph.D., Columbia University, 1991
- M.A., Columbia University, 1985
- B.A., State University of New York at Stony Brook, 1985
- B.A., State University of New York at Stony Brook, 1983
Selected Publications
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Gao Y, Yang W. Capture of a third Mg²⁺ is essential for catalyzing DNA synthesis. Science. 2016;352(6291):1334-7.
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Nakamura T, Zhao Y, Yamagata Y, Hua YJ, Yang W. Watching DNA polymerase η make a phosphodiester bond. Nature. 2012;487(7406):196-201.
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Gupta S, Gellert M, Yang W. Mechanism of mismatch recognition revealed by human MutSβ bound to unpaired DNA loops. Nat Struct Mol Biol. 2011;19(1):72-8.
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Zhao Y, Biertümpfel C, Gregory MT, Hua YJ, Hanaoka F, Yang W. Structural basis of human DNA polymerase η-mediated chemoresistance to cisplatin. Proc Natl Acad Sci U S A. 2012;109(19):7269-74.
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Lee YS, Gao Y, Yang W. How a homolog of high-fidelity replicases conducts mutagenic DNA synthesis. Nat Struct Mol Biol. 2015;22(4):298-303.
Related Scientific Focus Areas
Molecular Biology and Biochemistry
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Microbiology and Infectious Diseases
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