Wei Li, Ph.D.

Senior Investigator

Retinal Neurophysiology Section

NEI

Building 35, Room 2A108
35 Convent Drive
Bethesda, MD 20892-3739

301-496-6669

liwei2@nei.nih.gov

Research Topics

Our unit studies the structure and function of retinal synapses and circuits. Although we know the basic structure and major cell types of the retina, it remains much of a "black box" in terms of the connections and functions of these neurons. Our long-term research goal is to understand how the neuronal circuits are wired in this "black box" under normal conditions and how the circuits are altered during pathological processes. Both pieces of information will be crucial for the design of biological and/or prosthetic interventions aiming to restore vision in many types of blindness caused by retinal degenerative diseases. Here are some of the research topics: 1) we exploit a combination of anatomical, physiological, and imaging approaches to study synaptic connectivity using in vitro slice and flat-mount preparations of the ground squirrel retina. This is an excellent model system to study cone vision, as the ground squirrel is one of the rare mammals whose retina is cone-dominated and resembles the fovea of human retina. 2) We study synaptic alteration and adaptation in the ground squirrel retina during hibernation - another unique feature of the ground squirrel. 3) We investigate bioenergetics of the retina with a focus on cone photoreceptor mitochondria structure, function and dynamics. 4) We use a combination of genetically engineered mouse lines to study the development of certain synapses and circuits in the mouse retina.

Biography

Dr. Li received his medical degree in 1997 from Zhejiang University School of Medicine in China and his Ph.D. in Neuroscience in 2003 from the University of Texas at Houston where he studied the organization of reciprocal feedback synapse at the axon terminal of the retinal bipolar cell in Dr. Stephen Massey's laboratory. From 2003 to 2007, as a postdoctoral fellow, he worked with Dr. Steven DeVries at Northwestern University where he investigated synaptic connections between photoreceptors and bipolar neurons in a mammalian retina. Dr. Li joined NEI as the principal investigator of the Unit on Retinal Neurophysiology in 2007. His unit uses a variety of physiological and anatomical techniques to explore retinal synapses and circuits and their functions in vision.

Selected Publications

  1. Chen S, Li W. A color-coding amacrine cell may provide a blue-off signal in a mammalian retina. Nat Neurosci. 2012;15(7):954-6.

  2. Li W, Chen S, DeVries SH. A fast rod photoreceptor signaling pathway in the mammalian retina. Nat Neurosci. 2010;13(4):414-6.

  3. Li W, DeVries SH. Bipolar cell pathways for color and luminance vision in a dichromatic mammalian retina. Nat Neurosci. 2006;9(5):669-75.

  4. Miyagishima KJ, GrĂ¼nert U, Li W. Processing of S-cone signals in the inner plexiform layer of the mammalian retina. Vis Neurosci. 2014;31(2):153-63.

  5. Mehta B, Snellman J, Chen S, Li W, Zenisek D. Synaptic ribbons influence the size and frequency of miniature-like evoked postsynaptic currents. Neuron. 2013;77(3):516-27.


This page was last updated on August 28th, 2017