Veronica Alicia Alvarez, Ph.D.

Senior Investigator

Laboratory for Integrative Neuroscience; Section on Neuronal Structure

NIAAA

5625 Fishers Lane
Room TS-24, MSC 9411
Bethesda, MD 20892

301-443-7695

alvarezva@mail.nih.gov

Research Topics

Research in the Alvarez laboratory is focused on understanding the effects of drugs of abuse on synapses and neuronal connectivity with the purpose of revealing the cellular mechanisms that control reward-motivated behaviors and compulsive drug seeking. The studies focus on cocaine and ethanol, two prominent drugs of abuse in the US. Researchers in the laboratory of Dr. Alvarez apply multiple techniques ranging from approaches at the cellular and synaptic level to behavioral analysis and in vivo manipulations in wild-type and genetically-engineered mouse models.

Biography

Dr. Alvarez earned a Ph.D. degree in Neuroscience in 1997 from University of Buenos Aires, Argentina. She trained as a postdoctoral fellow with Dr. John Williams at the Vollum Institute, OHSU from 1998 to 2001 studying the firing properties of locus coerulues neurons and its modulation by opioids. She then trained with Dr. Bernardo Sabatini at Harvard Medical School from 2001-2007 where she studied mechanisms of functional and morphological plasticity at glutamatergic synapses using electrophysiology and two-photon imaging. In 2008, she established an independent research program at NIAAA where she is investigator and acting chief of the Section on Neuronal Structure.

Selected Publications

  1. Matsui A, Alvarez VA. Cocaine Inhibition of Synaptic Transmission in the Ventral Pallidum Is Pathway-Specific and Mediated by Serotonin. Cell Rep. 2018;23(13):3852-3863.

  2. Lemos JC, Friend DM, Kaplan AR, Shin JH, Rubinstein M, Kravitz AV, Alvarez VA. Enhanced GABA Transmission Drives Bradykinesia Following Loss of Dopamine D2 Receptor Signaling. Neuron. 2016;90(4):824-38.

  3. Dobbs LK, Kaplan AR, Lemos JC, Matsui A, Rubinstein M, Alvarez VA. Dopamine Regulation of Lateral Inhibition between Striatal Neurons Gates the Stimulant Actions of Cocaine. Neuron. 2016;90(5):1100-13.

  4. Shin JH, Adrover MF, Alvarez VA. Distinctive Modulation of Dopamine Release in the Nucleus Accumbens Shell Mediated by Dopamine and Acetylcholine Receptors. J Neurosci. 2017;37(46):11166-11180.

  5. Laguesse S, Morisot N, Shin JH, Liu F, Adrover MF, Sakhai SA, Lopez MF, Phamluong K, Griffin WC 3rd, Becker HC, Bender KJ, Alvarez VA, Ron D. Prosapip1-Dependent Synaptic Adaptations in the Nucleus Accumbens Drive Alcohol Intake, Seeking, and Reward. Neuron. 2017;96(1):145-159.e8.

Related Scientific Focus Areas


This page was last updated on September 28th, 2018