The research in the Chemotaxis Signal Section is focused on understanding the cellular and molecular mechanisms underlying chemotaxis of eukaryotes. Our research strategy to define the signaling network controlling chemotaxis relies on the use of the genetically amendable model organism Dictyostelium discoideum. We are developing cutting-edge live cell imaging technologies that visualize signaling events in live cells in real time, constructing computational models to comprehend the signaling network as a system, and discovering novel mechanisms involving G-protein-coupled receptor (GPCR)-mediated cell migration. Our long term goal is to elucidate molecular mechanisms underlying chemokine GPCR-mediated migration of immune cells and cancer cells.
Dr. Jin received his B.S. in biology from the Peking University, China, in 1984 and his Ph.D. from the department of biochemistry at the Robert Wood Johnson Medical School at Rutgers-UMDNJ in 1994. From 1994 to 2000, he was a postdoctoral fellow in the department of biological chemistry at Johns Hopkins University School of Medicine. Dr. Jin was appointed instructor in the department of cell biology and anatomy at Johns Hopkins University School of Medicine in 2001. In July 2001, he joined the Laboratory of Immunogenetics as a tenure-track investigator. In 2009, he became senior investigator at NIAID.
- Yan J, Mihaylov V, Xu X, Brzostowski JA, Li H, Liu L, Veenstra TD, Parent CA, Jin T. A Gβγ effector, ElmoE, transduces GPCR signaling to the actin network during chemotaxis. Dev Cell. 2012;22(1):92-103.
- Pan M, Neilson MP, Grunfeld AM, Cruz P, Wen X, Insall RH, Jin T. A G-protein-coupled chemoattractant receptor recognizes lipopolysaccharide for bacterial phagocytosis. PLoS Biol. 2018;16(5):e2005754.
- Xu X, Meckel T, Brzostowski JA, Yan J, Meier-Schellersheim M, Jin T. Coupling mechanism of a GPCR and a heterotrimeric G protein during chemoattractant gradient sensing in Dictyostelium. Sci Signal. 2010;3(141):ra71.
- Xu X, Wen X, Veltman DM, Keizer-Gunnink I, Pots H, Kortholt A, Jin T. GPCR-controlled membrane recruitment of negative regulator C2GAP1 locally inhibits Ras signaling for adaptation and long-range chemotaxis. Proc Natl Acad Sci U S A. 2017;114(47):E10092-E10101.
- Pan M, Xu X, Chen Y, Jin T. Identification of a Chemoattractant G-Protein-Coupled Receptor for Folic Acid that Controls Both Chemotaxis and Phagocytosis. Dev Cell. 2016;36(4):428-39.
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This page was last updated on Monday, August 12, 2019