Thomas Edward Wellems, M.D., Ph.D.
NIH Distinguished Investigator
Malaria Genetics Section
TW3 Building, Room 3E10
12735 Twinbrook Pkwy
Rockville, MD 20852
Investigations in the Malaria Genetics Section focus on the determinants of drug resistance, immune evasion, and disease virulence in malaria. Areas of study include the following:
- Antimalarial drug resistance and factors that affect clinical outcome after treatment
- Malaria protection conferred by human hemoglobinopathies and other red cell polymorphisms
- Antigenic variation by Plasmodium falciparum parasites
- Molecular mechanisms of malaria parasite infectivity and pathogenesis
Research activities on the National Institutes of Health (NIH) campus are integrated with field studies in Africa and Southeast Asia. Inquiries about predoctoral and postdoctoral fellowships as well as Ph.D. studentships in the NIH Graduate Partnership Program are welcome.
Dr. Wellems received his M.D. and Ph.D. from the University of Chicago. He completed his internal medicine residency at the Hospital of the University of Pennsylvania, and in 1984 he joined the Division of Intramural Research. He has directed the Malaria Genetics Section since 1991 and has served as chief of the Laboratory of Malaria and Vector Research since 2002. Dr. Wellems is a member of the U.S. National Academy of Sciences and the Institute of Medicine, is a past president of the American Society of Tropical Medicine and Hygiene, and serves on a number of advisory committees for foundations and public-private partnerships, including the Medicines for Malaria Venture.
For a biographical profile of Dr. Wellems, see Davis TH. Profile of Thomas E. Wellems. Proc Natl Acad Sci U S A. 2010 Aug 3;107(31):13567-9.
Papakrivos J, Sá JM, Wellems TE. Functional characterization of the Plasmodium falciparum chloroquine-resistance transporter (PfCRT) in transformed Dictyostelium discoideum vesicles. PLoS One. 2012;7(6):e39569.
Wellems TE, Fairhurst RM. An evolving picture of the interactions between malaria parasites and their host erythrocytes. Cell Res. 2012;22(3):453-6.
Wellems TE. Optimism, persistence, and our collective crystal ball. Am J Trop Med Hyg. 2010;83(1):1-6.
Sá JM, Twu O, Hayton K, Reyes S, Fay MP, Ringwald P, Wellems TE. Geographic patterns of Plasmodium falciparum drug resistance distinguished by differential responses to amodiaquine and chloroquine. Proc Natl Acad Sci U S A. 2009;106(45):18883-9.
Related Scientific Focus Areas
Microbiology and Infectious Diseases
This page was last updated on January 30th, 2017