The focus of the Helminth Immunology Section is the study of host resistance and immune regulation in parasitic helminth infections of global importance. The ultimate goal of this work is prevention of infection and disease. Our work focuses on both the host response to helminth infection and the molecular basis for parasitism in helminths and the prototypical responses they induce.
Much of our work involves the analysis of host-parasite interaction using in vitro systems and studies of cells from infected patients ex vivo. Current activities include 1) functional mapping of the earliest host-parasite interaction that influences the polarized immune responses that are the hallmarks of these infections; 2) genomic and proteomic definition of each of the filarial parasites to identify parasite-encoded therapeutic, diagnostic, and vaccine-related targets; 3) studies of pathogenesis underlying disease manifestations (e.g., elephantiasis) in filarial infections; 4) studies of immunologic bystander effects of chronic helminth infection on non-parasitic infections (HIV, tuberculosis, malaria), atopy, and autoimmune diseases; 5) the regulation of igE and eosinophilia in the context of human helminth infections.
The Clinical Parasitology Section is an interdisciplinary group of clinically trained LPD staff members who oversee the clinical research portfolio ad provide clinical care, consultations, and training in tropical medicine and parasitology.
The overriding goals of this program are
- To gain insight into the clinical syndromes associated with parasitic infections
- To understand and help define the pathogenesis underlying clinical disease
- To identify better ways of treating individual infections and to prevent secondary consequences of treatment
- To develop better diagnostic tools for the species-specific diagnosis of active parasitic infection
Although the section has protocols to see patients with any parasitic infection, the majority of patients have neurocysticercosis, filarial infections (lymphatic filariasis, onchocerciasis, loiasis, mansonellosis), strongyloidiasis, hookwork infections, ascaraisis, giardiasis, echinococcosis, and leishmaniasis. We occasionally see patients with gnathostomiasis, African trypanosomiasis, Chagas disease, and malaria, among others.
Dr. Nutman received his A.B. from Brown University and his M.D. from the University of Cincinnati College of Medicine. He did an internal medicine residency at New York University (Bellevue) and postdoctoral training in the Laboratory of Parasitic Diseases (LPD). He is board certified in internal medicine and allergy and immunology. He also holds a diploma/certificate in tropical medicine and travelers’ health. He has been at NIH in the Laboratory of Parasitic Diseases since 1982, where he is currently deputy chief, as well as chief of both the Helminth Immunology Section and the Clinical Parasitology Section. In addition, he is the director of the NIAID International Center for Excellence in Research (ICER) located in Chennai, India, as well as director of the filariasis unit at the NIAID ICER in Mali. He is on numerous advisory committees and editorial boards and holds patents related to parasite diagnosis and vaccine development. He is the author or coauthor of over 500 papers and book chapters and has received multiple awards for his work in tropical medicine and immunology.
- Gazzinelli-Guimaraes PH, Sanku G, Sette A, Weiskopf D, Schaughency P, Lack J, Nutman TB. Antigenic Determinants of SARS-CoV-2-Specific CD4+ T Cell Lines Reveals M Protein-Driven Dysregulation of Interferon Signaling. Front Immunol. 2022;13:883159.
- Gazzinelli-Guimaraes PH, de Queiroz Prado R, Ricciardi A, Bonne-Année S, Sciurba J, Karmele EP, Fujiwara RT, Nutman TB. Allergen presensitization drives an eosinophil-dependent arrest in lung-specific helminth development. J Clin Invest. 2019;129(9):3686-3701.
- Gazzinelli-Guimaraes PH, Bennuru S, de Queiroz Prado R, Ricciardi A, Sciurba J, Kupritz J, Moser M, Kamenyeva O, Nutman TB. House dust mite sensitization drives cross-reactive immune responses to homologous helminth proteins. PLoS Pathog. 2021;17(3):e1009337.
- Ricciardi A, Bennuru S, Tariq S, Kaur S, Wu W, Elkahloun AG, Arakelyan A, Shaik J, Dorward DW, Nutman TB, Tolouei Semnani R. Extracellular vesicles released from the filarial parasite Brugia malayi downregulate the host mTOR pathway. PLoS Negl Trop Dis. 2021;15(1):e0008884.
- Ricciardi A, Nutman TB. IL-10 and Its Related Superfamily Members IL-19 and IL-24 Provide Parallel/Redundant Immune-Modulation in Loa loa Infection. J Infect Dis. 2021;223(2):297-305.
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This page was last updated on Friday, August 19, 2022