Suzette Alise Priola, Ph.D.

Senior Investigator

TSE / Prion Molecular Biology Section


Rocky Mountain Laboratories
Building 3, Room 3115
903 South 4th Street
Hamilton, MT 59840


Research Topics

Research in this laboratory focuses on the molecular basis of disease in transmissible spongiform encephalopathy (TSE) diseases. TSEs are a group of neurodegenerative diseases that include sporadic and familial Creutzfeldt-Jakob disease (CJD) in humans: scrapie in sheep; chronic wasting disease (CWD) in deer, elk, and moose; and bovine spongiform encephalopathy (BSE) in cattle.

The conversion of the normally soluble and protease-sensitive host prion protein, PrP-sen, to an insoluble and partially protease-resistant form, PrP-res, is a key event in TSE pathogenesis and PrP is necessary for disease to occur. Using both in vitro and in vivo model systems, our laboratory studies the role of PrP-sen and PrP-res in several aspects of TSE pathogenesis, including: 1) the molecular pathogenesis of TSE species barriers and strains; 2) the mechanism of formation of amyloid and non-amyloid forms of PrP-res, especially with regard to familial TSE diseases; 3) the establishment of acute versus chronic TSE infection; and 4) the development of TSE vaccines and therapeutics.


Dr. Priola received her Ph.D. in microbiology and immunology in 1990 from the University of California, Los Angeles. In 1991, she joined the Rocky Mountain Laboratories where she is now a senior investigator. She is a former chair of the FDA TSE Advisory Committee and is currently chief of the TSE/Prion Molecular Biology Section. She currently serves on the editorial board of the journal Virology.

Selected Publications

  1. Priola SA, Raines A, Caughey WS. Porphyrin and phthalocyanine antiscrapie compounds. Science. 2000;287(5457):1503-6.
  2. Ward A, Hollister JR, McNally K, Ritchie DL, Zanusso G, Priola SA. Transmission characteristics of heterozygous cases of Creutzfeldt-Jakob disease with variable abnormal prion protein allotypes. Acta Neuropathol Commun. 2020;8(1):83.
  3. Faris R, Moore RA, Ward A, Sturdevant DE, Priola SA. Mitochondrial Respiration Is Impaired during Late-Stage Hamster Prion Infection. J Virol. 2017;91(18).

Related Scientific Focus Areas

This page was last updated on Saturday, August 19, 2023