Stephen H. Leppla, Ph.D., B.S.

Senior Investigator

Microbial Pathogenesis Section

NIAID/DIR

Building 33, Room 1W20B7
33 North Drive
Bethesda, MD 20892

301-594-2865

sleppla@niaid.nih.gov

Research Topics

The Microbial Pathogenesis Section studies bacterial diseases related to biodefense pathogens. Research focuses on identification and analysis of bacterial virulence factors and their genetic regulation; structure-function analysis of bacterial proteins and other factors; disease pathogenesis; and development of diagnostics, vaccines, and therapeutics.

Biography

Dr. Leppla earned a B.S. in biology from the California Institute of Technology and a Ph.D. in biochemistry from the University of Wisconsin. After postdoctoral study at the University of California-Berkeley and Brown University, he became a research scientist at the U.S. Army Medical Research Institute of Infectious Diseases in Frederick, Maryland. He moved to the National Institutes of Health in 1989 and to NIAID in 2003.

Selected Publications

  1. Chen KH, Liu S, Leysath CE, Miller-Randolph S, Zhang Y, Fattah R, Bugge TH, Leppla SH. Anthrax Toxin Protective Antigen Variants That Selectively Utilize either the CMG2 or TEM8 Receptors for Cellular Uptake and Tumor Targeting. J Biol Chem. 2016;291(42):22021-22029.

  2. Liu S, Liu J, Ma Q, Cao L, Fattah RJ, Yu Z, Bugge TH, Finkel T, Leppla SH. Solid tumor therapy by selectively targeting stromal endothelial cells. Proc Natl Acad Sci U S A. 2016;113(28):E4079-87.

  3. Pomerantsev AP, Rappole C, Chang Z, Chahoud M, Leppla SH. The IntXO-PSL Recombination System Is a Key Component of the Second Maintenance System for Bacillus anthracis Plasmid pXO1. J Bacteriol. 2016;198(14):1939-51.

  4. Wein AN, Peters DE, Valivullah Z, Hoover BJ, Tatineni A, Ma Q, Fattah R, Bugge TH, Leppla SH, Liu S. An anthrax toxin variant with an improved activity in tumor targeting. Sci Rep. 2015;5:16267.

  5. Liu S, Zhang Y, Moayeri M, Liu J, Crown D, Fattah RJ, Wein AN, Yu ZX, Finkel T, Leppla SH. Key tissue targets responsible for anthrax-toxin-induced lethality. Nature. 2013;501(7465):63-8.


This page was last updated on February 15th, 2017