Stella Koutros, Ph.D., M.P.H.

Investigator

Occupational and Environmental Epidemiology Branch

NCI/DCEG

9609 Medical Center Drive
Room SG/6E616
Rockville, MD 20850

240-276-7165

koutross@mail.nih.gov

Research Topics

Dr. Stella Koutros’s research involves the design and conduct of epidemiologic investigations to evaluate occupational exposures as risk factors for cancer. She employs state-of-the-art exposure assessment methods and molecular studies within highly exposed populations to identify the etiology and clarify the biological mechanisms underlying chemical-induced carcinogenesis. Areas of interest include exposures occurring in the workplace and those contributing to the etiology of bladder cancer.

Occupation and Industry-based Exposures

Dr. Koutros leads several efforts in large occupation and industry-based cohort studies studying the impact of high levels of exposure to several important chemicals that have large public health and regulatory concerns. Specific areas of interest include:

  • Pesticide exposures as risk factors for cancer. Areas of focus include exposure to specific organophosphate insecticides and risk for aggressive prostate cancer and bladder cancer as well as the interaction between agricultural pesticide use and genetic susceptibility on cancer risk.
  • Acrylonitrile and cancer mortality. Areas of focus include suggested elevated risks for cancers of the lung and bladder among acrylonitrile-exposed workers.
  • Diesel exhaust and cancer mortality in a cohort of workers exposed to diesel exhaust at eight U.S. non-metal mining facilities.

Bladder Cancer

Occupational exposures are a leading risk factor for bladder cancer, second only to smoking. Dr. Koutros is currently leading efforts within large case-control studies of bladder cancer to identify important occupational exposures that might influence risk. Dr. Koutros and her collaborators are examining potential gene-environment interactions as well as incorporating important somatic variation and bladder tumor marker data to integrate exposure, germline genetic variation, and somatic changes to gain insights into the etiology of bladder carcinogenesis.

Biography

Dr. Koutros received her M.P.H. and Ph.D. in epidemiology from Yale University. She completed her doctoral work through the Yale-NCI partnership training program in cancer epidemiology, conducting research in the Occupational and Environmental Epidemiology Branch (OEEB). In 2008, upon completion of her doctorate, she became a fellow in OEEB; she was appointed to the position of tenure-track investigator in 2015.

Selected Publications

  1. Koutros S, Beane Freeman LE, Lubin JH, Heltshe SL, Andreotti G, Barry KH, DellaValle CT, Hoppin JA, Sandler DP, Lynch CF, Blair A, Alavanja MC. Risk of total and aggressive prostate cancer and pesticide use in the Agricultural Health Study. Am J Epidemiol. 2013;177(1):59-74.

  2. Koutros S, Beane Freeman LE, Berndt SI, Andreotti G, Lubin JH, Sandler DP, Hoppin JA, Yu K, Li Q, Burdette LA, Yuenger J, Yeager M, Alavanja MC. Pesticide use modifies the association between genetic variants on chromosome 8q24 and prostate cancer. Cancer Res. 2010;70(22):9224-33.

  3. Koutros S, Langseth H, Grimsrud TK, Barr DB, Vermeulen R, Portengen L, Wacholder S, Freeman LE, Blair A, Hayes RB, Rothman N, Engel LS. Prediagnostic Serum Organochlorine Concentrations and Metastatic Prostate Cancer: A Nested Case-Control Study in the Norwegian Janus Serum Bank Cohort. Environ Health Perspect. 2015;123(9):867-72.

  4. Koutros S, Silverman DT, Alavanja MC, Andreotti G, Lerro CC, Heltshe S, Lynch CF, Sandler DP, Blair A, Beane Freeman LE. Occupational exposure to pesticides and bladder cancer risk. Int J Epidemiol. 2016;45(3):792-805.


This page was last updated on February 11th, 2019