Shanshan Zhao, Ph.D.

Investigator

Biostatistics & Computational Biology Branch

NIEHS

A328 Rall Building
111 T W Alexander Dr
Research Triangle Park, NC 27709

919-316-4869

shanshan.zhao@nih.gov

Research Topics

Zhao is interested in statistical methods related to biomarkers. First, biomarkers have the potential to elucidate the key biological pathways through which treatment may affect clinical outcomes. However, measurement error in the biomarker measures can obscure this ability. She developed correction methods for the Cox model in the mediation analysis setting, when the mediator is measured with error. Second, biomarkers can be used for diagnosis of cancer and other diseases. She is interested in efficient designs of biomarker studies, such as sequential design and quota-sampling, with the aim to conserve biospecimens and reduce cost. Third, she is involved in studies with epigenetic biomarkers, which serve as mediators between environmental factors and many diseases.

Zhao is also focusing on multivariate failure time data analysis. Although the analysis of univariate failure time has been well developed, there are still big gaps in multivariate failure time methodology. In practice with rare diseases, we may not be able to observe the disease of interest in all study participants (i.e., these subjects are censored). However, we might observe other events during the study. If the observed events are related to the main study outcome, we may be able to use the data to fill in information about the main study outcome on those censored participants. For example, a study to predict time to stroke can benefit from information on time to coronary heart disease, given that these two outcomes are related. In addition, we might be interested in understanding how times to different diseases are related to each other, and how disease onset times relate within families. Zhao works on semiparametric models for bivariate failure times to address these issues.

Biography

Dr. Zhao received her Ph.D. in Biostatistics from the University of Washington in 2012. She was a postdoctoral fellow at the Fred Hutchinson Cancer Research Center from 2012 to 2014. She joined NIEHS in 2015.

Selected Publications

  1. Zhao S, Prentice RL. Covariate measurement error correction methods in mediation analysis with failure time data. Biometrics. 2014;70(4):835-44.

  2. Zhao S, Chlebowski RT, Anderson GL, Kuller LH, Manson JE, Gass M, Patterson R, Rohan TE, Lane DS, Beresford SA, Lavasani S, Rossouw JE, Prentice RL. Sex hormone associations with breast cancer risk and the mediation of randomized trial postmenopausal hormone therapy effects. Breast Cancer Res. 2014;16(2):R30.

  3. Prentice RL, Zhao S. Nonparametric estimation of the multivariate survivor function: the multivariate Kaplan-Meier estimator. Lifetime Data Anal. 2016.

  4. Zhao S, Zheng Y, Prentice RL, Feng Z. Two-stage biomarker panel study and estimation allowing early termination for futility. Biostatistics. 2015;16(4):799-812.

  5. Nelson JC, Cook AJ, Yu O, Zhao S, Jackson LA, Psaty BM. Methods for observational post-licensure medical product safety surveillance. Stat Methods Med Res. 2015;24(2):177-93.


This page was last updated on March 31st, 2015