Sergi Ferré, M.D., Ph.D.

Senior Investigator

Molecular Targets and Medications Discovery Branch, Integrative Neurobiology Section

NIDA

Triad Technology Center
333 Cassell Drive
Baltimore, MD 21224

443-740-2647

SFerre@intra.nida.nih.gov

Research Topics

We are interested in the role of G protein-coupled receptor (GPCR) oligomers as targets for drug development in neuropsychiatric disorders. GPCR oligomers are higher order molecular entities that are the result of combinatorial evolution and endowed with unique biochemical and functional properties that could be harnessed for therapeutic purposes. Our studies are leading to a new theoretical view of GPCR physiology and pharmacology. The pentameric structure constituted by one GPCR homodimer and one heterotrimeric G protein seems to provide a main functional unit and oligomeric entities can be viewed as multiples of dimers. GPCR heteromers can then be preferentially constituted by heteromers of homodimers coupled to their cognate G protein. The GPCR heterotetramer provides the frame for canonical antagonistic interactions between Gs- and Gi- coupled receptors. Allosteric mechanisms determine a multiplicity of possible unique pharmacological properties of GPCR homomers and heteromers. We have demonstrated that some general mechanisms apply particularly at the level of ligand-binding properties. But in addition to ligand-binding properties, unique properties for each GPCR oligomer emerge in relation to different intrinsic efficacy of ligands for different signaling pathways (functional selectivity). This gives a rationale for the use of GPCR oligomers, and particularly heteromers, as novel targets for drug development.

Selected Publications

  1. Belcher AM, Volkow ND, Moeller FG, Ferré S. Personality traits and vulnerability or resilience to substance use disorders. Trends Cogn Sci. 2014;18(4):211-7.

  2. Ferré S, Casadó V, Devi LA, Filizola M, Jockers R, Lohse MJ, Milligan G, Pin JP, Guitart X. G protein-coupled receptor oligomerization revisited: functional and pharmacological perspectives. Pharmacol Rev. 2014;66(2):413-34.

  3. Ferré S. The GPCR heterotetramer: challenging classical pharmacology. Trends Pharmacol Sci. 2015;36(3):145-52.

  4. Ferré S, Baler R, Bouvier M, Caron MG, Devi LA, Durroux T, Fuxe K, George SR, Javitch JA, Lohse MJ, Mackie K, Milligan G, Pfleger KD, Pin JP, Volkow ND, Waldhoer M, Woods AS, Franco R. Building a new conceptual framework for receptor heteromers. Nat Chem Biol. 2009;5(3):131-4.


This page was last updated on November 2nd, 2018