Serena M. Dudek, Ph.D.

Senior Investigator

Neurobiology Laboratory / Synaptic & Developmental Plasticity Group


Rall Building
111 T W Alexander Dr
Research Triangle Park, NC 27709


Research Topics

One physiological function of the human brain is adapting the organism to its environment. In the brain, a primary effect of sensory exposures during postnatal development is on the strength of the synaptic contacts between neurons. Our main interest, therefore, has been to determine the molecular basis of long lasting synaptic plasticity. We focus on three aims in my laboratory: 1) how signals are rapidly transmitted to the nucleus to consolidate synaptic strengthening, 2) how synapses are weakened and eliminated during critical periods of postnatal development, and 3) how the process of synaptic plasticity is regulated in different brain regions. We use a diverse collection of molecular, biochemical, electrophysiological, and imaging techniques, primarily in brain slice preparations and neuron cultures from rodents. Recently, we have focused our efforts on a single region of the hippocampus, Hippocampal Area CA2, as neurons in this area express a number of genes distinct from the other CA regions that we found to regulate synaptic plasticity such as long-term depression (LTD) and long-term potentiation (LTP).


Dr. Dudek received her B.S. in Biology in 1986 from the University of California at Irvine, where she began working on synaptic plasticity in the hippocampus with Gary Lynch. In 1992, she earned her Ph.D. in Neuroscience from Brown University, where she worked with Mark Bear on long-term synaptic depression in the hippocampus. Following postdoctoral work at the University of Alabama at Birmingham and at the NICHD, Dr. Dudek moved to NIEHS as an Investigator in 2001. Now a Senior Investigator, she directs laboratory studies on the cellular mechanisms of synaptic plasticity in the adult and developing mammalian cortex. She is the recipient of the 2009 A.E. Bennett Research Award from the Society of Biological Psychiatry.

Selected Publications

  1. Carstens KE, Lustberg DJ, Shaughnessy EK, McCann KE, Alexander GM, Dudek SM. Perineuronal net degradation rescues CA2 plasticity in a mouse model of Rett syndrome. J Clin Invest. 2021;131(16).
  2. McCann KE, Lustberg DJ, Shaughnessy EK, Carstens KE, Farris S, Alexander GM, Radzicki D, Zhao M, Dudek SM. Novel role for mineralocorticoid receptors in control of a neuronal phenotype. Mol Psychiatry. 2021;26(1):350-364.
  3. Farris S, Ward JM, Carstens KE, Samadi M, Wang Y, Dudek SM. Hippocampal Subregions Express Distinct Dendritic Transcriptomes that Reveal Differences in Mitochondrial Function in CA2. Cell Rep. 2019;29(2):522-539.e6.
  4. Alexander GM, Brown LY, Farris S, Lustberg D, Pantazis C, Gloss B, Plummer NW, Jensen P, Dudek SM. CA2 neuronal activity controls hippocampal low gamma and ripple oscillations. Elife. 2018;7.
  5. Dudek SM, Alexander GM, Farris S. Rediscovering area CA2: unique properties and functions. Nat Rev Neurosci. 2016;17(2):89-102.

Related Scientific Focus Areas

This page was last updated on Friday, February 23, 2024