Rose Yang, Ph.D., M.P.H.

Senior Investigator

Integrative Tumor Epidemiology Branch

NCI/DCEG

9609 Medical Center Drive
Room SG/7E104
Rockville, MD 20850

240-276-7226

royang@mail.nih.gov

Research Topics

In her research on familial cancers—including melanoma and dysplastic nevi syndrome, and chordoma—Dr. Yang employs cutting-edge genomic technologies and novel statistical approaches to evaluate copy number and exome sequencing variants, as well as mRNA expression, miRNA expression, DNA methylation, chromatin modification, and telomere length in disease susceptibility. Most recently, Dr. Yang and her colleagues identified a rare inherited mutation in a gene involved in maintaining telomere stability in melanoma families, further supporting a role for abnormal telomeres in the development of melanoma.

In her investigation of etiologic heterogeneity of breast cancer, Dr. Yang characterizes the molecular signature of tumors using tissue microarray and integrated tumor profiling analyses to identify risk factors for specific cancer subtypes. She is leading breast cancer studies in mainland China, Hong Kong, and Malaysia to identify distinct molecular alterations in tumors and adjacent normal tissues among Asian women, and to examine the associations of these molecular changes with genetic and environmental risk factors, breast tissue composition and density, and breast cancer subtypes.

Biography

Dr. Yang received a Ph.D. in physiology from the Lombardi Cancer Center, Georgetown University in 1999 and an M.P.H. in epidemiology from the Johns Hopkins Bloomberg School of Public Health in 2003. She joined the Genetic Epidemiology Branch (GEB) in 2000 as a postdoctoral fellow, became a tenure-track investigator in 2006, and was appointed senior investigator upon receiving NIH scientific tenure in 2014. She received NCI Director’s Intramural Innovation Awards in 2007 and 2009. Dr. Yang serves on the editorial board for Cancer Epidemiology, Biomarkers & Prevention, and is an adjunct associate professor at the Chinese University of Hong Kong. Her research interests include the genetics of familial cutaneous malignant melanoma/dysplastic nevi syndrome and chordoma, and etiologic heterogeneity of breast cancer.

Selected Publications

  1. Yang XR, Ng D, Alcorta DA, Liebsch NJ, Sheridan E, Li S, Goldstein AM, Parry DM, Kelley MJ. T (brachyury) gene duplication confers major susceptibility to familial chordoma. Nat Genet. 2009;41(11):1176-8.

  2. Yang XR, Chang-Claude J, Goode EL, Couch FJ, Nevanlinna H, Milne RL, Gaudet M, Schmidt MK, Broeks A, Cox A, Fasching PA, Hein R, Spurdle AB, Blows F, Driver K, Flesch-Janys D, Heinz J, Sinn P, Vrieling A, Heikkinen T, Aittomäki K, Heikkilä P, Blomqvist C, Lissowska J, Peplonska B, Chanock S, Figueroa J, Brinton L, Hall P, Czene K, Humphreys K, Darabi H, Liu J, Van 't Veer LJ, van Leeuwen FE, Andrulis IL, Glendon G, Knight JA, Mulligan AM, O'Malley FP, Weerasooriya N, John EM, Beckmann MW, Hartmann A, Weihbrecht SB, Wachter DL, Jud SM, Loehberg CR, Baglietto L, English DR, Giles GG, McLean CA, Severi G, Lambrechts D, Vandorpe T, Weltens C, Paridaens R, Smeets A, Neven P, Wildiers H, Wang X, Olson JE, Cafourek V, Fredericksen Z, Kosel M, Vachon C, Cramp HE, Connley D, Cross SS, Balasubramanian SP, Reed MW, Dörk T, Bremer M, Meyer A, Karstens JH, Ay A, Park-Simon TW, Hillemanns P, Arias Pérez JI, Menéndez Rodríguez P, Zamora P, Benítez J, Ko YD, Fischer HP, Hamann U, Pesch B, Brüning T, Justenhoven C, Brauch H, Eccles DM, Tapper WJ, Gerty SM, Sawyer EJ, Tomlinson IP, Jones A, Kerin M, Miller N, McInerney N, Anton-Culver H, Ziogas A, Shen CY, Hsiung CN, Wu PE, Yang SL, Yu JC, Chen ST, Hsu GC, Haiman CA, Henderson BE, Le Marchand L, Kolonel LN, Lindblom A, Margolin S, Jakubowska A, Lubiński J, Huzarski T, Byrski T, Górski B, Gronwald J, Hooning MJ, Hollestelle A, van den Ouweland AM, Jager A, Kriege M, Tilanus-Linthorst MM, Collée M, Wang-Gohrke S, Pylkäs K, Jukkola-Vuorinen A, Mononen K, Grip M, Hirvikoski P, Winqvist R, Mannermaa A, Kosma VM, Kauppinen J, Kataja V, Auvinen P, Soini Y, Sironen R, Bojesen SE, Ørsted DD, Kaur-Knudsen D, Flyger H, Nordestgaard BG, Holland H, Chenevix-Trench G, Manoukian S, Barile M, Radice P, Hankinson SE, Hunter DJ, Tamimi R, Sangrajrang S, Brennan P, McKay J, Odefrey F, Gaborieau V, Devilee P, Huijts PE, Tollenaar RA, Seynaeve C, Dite GS, Apicella C, Hopper JL, Hammet F, Tsimiklis H, Smith LD, Southey MC, Humphreys MK, Easton D, Pharoah P, Sherman ME, Garcia-Closas M. Associations of breast cancer risk factors with tumor subtypes: a pooled analysis from the Breast Cancer Association Consortium studies. J Natl Cancer Inst. 2011;103(3):250-63.

  3. Shi J, Yang XR, Ballew B, Rotunno M, Calista D, Fargnoli MC, Ghiorzo P, Bressac-de Paillerets B, Nagore E, Avril MF, Caporaso NE, McMaster ML, Cullen M, Wang Z, Zhang X, NCI DCEG Cancer Sequencing Working Group., NCI DCEG Cancer Genomics Research Laboratory., French Familial Melanoma Study Group., Bruno W, Pastorino L, Queirolo P, Banuls-Roca J, Garcia-Casado Z, Vaysse A, Mohamdi H, Riazalhosseini Y, Foglio M, Jouenne F, Hua X, Hyland PL, Yin J, Vallabhaneni H, Chai W, Minghetti P, Pellegrini C, Ravichandran S, Eggermont A, Lathrop M, Peris K, Scarra GB, Landi G, Savage SA, Sampson JN, He J, Yeager M, Goldin LR, Demenais F, Chanock SJ, Tucker MA, Goldstein AM, Liu Y, Landi MT. Rare missense variants in POT1 predispose to familial cutaneous malignant melanoma. Nat Genet. 2014;46(5):482-6.

  4. Liang X, Pfeiffer RM, Li WQ, Brossard M, Burke LS, Wheeler W, Calista D, Fargnoli MC, Ghiorzo P, Peris K, Bianchi-Scarra G, Chaudru V, Zelenika D, Maeder D, Burdette L, Yeager M, Chanock S, Landi MT, Demenais F, Tucker MA, Goldstein AM, Yang XR. Association of genetic variants in CDK6 and XRCC1 with the risk of dysplastic nevi in melanoma-prone families. J Invest Dermatol. 2014;134(2):481-487.


This page was last updated on March 9th, 2017