Ranjan Sen, Ph.D.

Senior Investigator

Laboratory of Molecular Biology and Immunology

NIA

251 Bayview Boulevard
Suite 100
Baltimore, MD 21224

410-558-8630

senra@mail.nih.gov

Research Topics

B and T cell differentiation share several common features. B lymphopoiesis takes place in the bone marrow where environmental cues commit multipotent cells to the B lineage. Close to the point of lineage commitment gene rearrangements are initiated at the immunoglobulin heavy chain (IgH) gene locus. Activation of the locus and subsequent V(D)J recombination is regulated in complex ways, and one of our objectives is to understand the molecular mechanisms that underlie this complexity. A parallel pathway operates in the thymus where multipotent cells commit to the T lineage. One important consequence is the activation and recombination of T cell receptor (TCR) b chain genes. The TCRb gene enhancer has been shown to be essential in this process and we have used it to probe this differentiation step.

Biography

Dr. Sen received his Ph.D., degree in chemistry from Columbia University in 1982. He made the transition to molecular biology as a postdoctoral fellow in David Baltimore's laboratory at M.I.T. and the Whitehead Institute. During this stage he developed his current interests in gene regulation. In 1987 Dr. Sen was appointed Assistant Professor in the Department of Biology and Rosenstiel Research Center at Brandies University. He earned tenure in 1991 and was promoted to Professor of Biology in 1998. He moved to his present position as Chief, Laboratory of Cellular and Molecular Biology, National Institute on Aging in 2003.

Selected Publications

  1. Qiu X, Kumari G, Gerasimova T, Du H, Labaran L, Singh A, De S, Wood WH 3rd, Becker KG, Zhou W, Ji H, Sen R. Sequential Enhancer Sequestration Dysregulates Recombination Center Formation at the IgH Locus. Mol Cell. 2018;70(1):21-33.e6.

  2. Sen R. A Pioneer's Tail. Immunity. 2016;44(3):516-518.

  3. Ward A, Kumari G, Sen R, Desiderio S. The RAG-2 Inhibitory Domain Gates Accessibility Of The V(D)J Recombinase To Chromatin. Mol Cell Biol. 2018.

  4. Montefiori L, Wuerffel R, Roqueiro D, Lajoie B, Guo C, Gerasimova T, De S, Wood W, Becker KG, Dekker J, Liang J, Sen R, Kenter AL. Extremely Long-Range Chromatin Loops Link Topological Domains to Facilitate a Diverse Antibody Repertoire. Cell Rep. 2016;14(4):896-906.

  5. Bektas A, Schurman SH, Sen R, Ferrucci L. Human T cell immunosenescence and inflammation in aging. J Leukoc Biol. 2017;102(4):977-988.


This page was last updated on August 21st, 2018