Rafael Daniel Camerini-Otero, M.D., Ph.D.
Genetics and Biochemistry Branch
Building 5, Room 205A
5 Memorial Drive
Bethesda, MD 20814
The ultimate goal of our research is improve the health of individuals with inherited and congenital conditions and diseases.
My laboratory is interested in the biochemistry and molecular biology of homologous recombination in prokaryotes and eukaryotes. The focus had been on the first homology-dependent step in homologous recombination, the homologous pairing of DNAs. We have been studying the underlying biochemical mechanism to understand the biology of genetic recombination and to devise new strategies to manipulate complex genomes in vitro and, in the future, in vivo, and the DNA-protein complexes involved. In addition, we have been studying the biochemistry and molecular biology of mouse meiosis and evolutionary genomics. Most recently, we have been investigating novel approaches to map recombination hotspots in a variety of mammals including humans.
- M.D., Ph.D., New York University, 1973
- B.S., Massachusetts Institute of Technology, 1966
Dai J, Voloshin O, Potapova S, Camerini-Otero RD. Meiotic Knockdown and Complementation Reveals Essential Role of RAD51 in Mouse Spermatogenesis. Cell Rep. 2017;18(6):1383-1394.
Brick K, Smagulova F, Khil P, Camerini-Otero RD, Petukhova GV. Genetic recombination is directed away from functional genomic elements in mice. Nature. 2012;485(7400):642-5.
Smagulova F, Brick K, Pu Y, Camerini-Otero RD, Petukhova GV. The evolutionary turnover of recombination hot spots contributes to speciation in mice. Genes Dev. 2016;30(3):266-80.
Smagulova F, Gregoretti IV, Brick K, Khil P, Camerini-Otero RD, Petukhova GV. Genome-wide analysis reveals novel molecular features of mouse recombination hotspots. Nature. 2011;472(7343):375-8.
Pratto F, Brick K, Khil P, Smagulova F, Petukhova GV, Camerini-Otero RD. DNA recombination. Recombination initiation maps of individual human genomes. Science. 2014;346(6211):1256442.
Related Scientific Focus Areas
Genetics and Genomics
Molecular Biology and Biochemistry
This page was last updated on October 5th, 2017