Rachel R. Caspi, Ph.D.
Building 10, Room 10N248F
10 Center Drive
Bethesda, MD 20892
Because basic cellular and molecular mechanisms involved in disease are often difficult to study in humans, our experimental approaches rely heavily on animal models. Cutting edge approaches involving gene manipulated mice, multicolor flow cytometry, genomic and transcriptomic analyses, the study of the microbiome and bioinformatic predictions are used to dissect fundamental immune processes in health and disease. The approaches and conclusions are broadly generalizable to other autoimmune and inflammatory disease models and their human counterparts. The goal is to use the knowledge gained from these studies for designing novel and rational strategies for immunotherapy.
Dr. Caspi's research centers on tolerance and autoimmunity to immunologically privileged retinal antigens in animal models of autoimmune uveitis, a potentially blinding human disease. She developed the mouse model uveitis, now in use worldwide. Her studies have elucidated many basic mechanisms of pathogenesis and helped to devise clinically relevant immunotherapeutic approaches. She is particularly well known for her work on effector and regulatory T cells in pathogenesis of ocular autoimmunity. The work she and her group have published is broadly applicable to autoimmunity in general. She is the recipient of numerous honors and awards, most recent of which was the 2010 Friedenwald award, one of the two highest awards in the field of vision research, and has authored and co-authored >200 publications.
Agarwal RK, Kang Y, Zambidis E, Scott DW, Chan CC, Caspi RR. Retroviral gene therapy with an immunoglobulin-antigen fusion construct protects from experimental autoimmune uveitis. J Clin Invest. 2000;106(2):245-52.
Avichezer D, Grajewski RS, Chan CC, Mattapallil MJ, Silver PB, Raber JA, Liou GI, Wiggert B, Lewis GM, Donoso LA, Caspi RR. An immunologically privileged retinal antigen elicits tolerance: major role for central selection mechanisms. J Exp Med. 2003;198(11):1665-76.
Luger D, Silver PB, Tang J, Cua D, Chen Z, Iwakura Y, Bowman EP, Sgambellone NM, Chan CC, Caspi RR. Either a Th17 or a Th1 effector response can drive autoimmunity: conditions of disease induction affect dominant effector category. J Exp Med. 2008;205(4):799-810.
Horai R, Zárate-Bladés CR, Dillenburg-Pilla P, Chen J, Kielczewski JL, Silver PB, Jittayasothorn Y, Chan CC, Yamane H, Honda K, Caspi RR. Microbiota-Dependent Activation of an Autoreactive T Cell Receptor Provokes Autoimmunity in an Immunologically Privileged Site. Immunity. 2015;43(2):343-53.
St Leger AJ, Desai JV, Drummond RA, Kugadas A, Almaghrabi F, Silver P, Raychaudhuri K, Gadjeva M, Iwakura Y, Lionakis MS, Caspi RR. An Ocular Commensal Protects against Corneal Infection by Driving an Interleukin-17 Response from Mucosal γδ T Cells. Immunity. 2017;47(1):148-158.e5.
Related Scientific Focus Areas
Genetics and Genomics
Microbiology and Infectious Diseases
This page was last updated on September 12th, 2019