Priyanka Sivakami Narayan, Ph.D.

Stadtman Investigator

Human Disease Section, Genetics & Biochemistry Branch

NIDDK

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Building NIHBC 10 - Clinical Center, Room 9N311
10 Center Dr
Bethesda, MD 20892

+1 301 827 3189

priyanka.narayan@nih.gov

Research Topics

Neurodegenerative diseases like Alzheimer’s disease are a growing public health concern. The extended and devastating course of these diseases, the increasing patient population, and the lack of therapeutic options all contribute to this pressing public health crisis. Our lab studies the ways in which genetic and environmental factors alter fundamental cellular pathways to increase susceptibility or improve resilience to neurodegenerative diseases like Alzheimer’s disease. We are pursuing these scientific questions with the ultimate goal of identifying novel therapeutic or preventative mechanisms for neurodegenerative diseases. Our research combines techniques from biochemistry, genetic screening, and neurobiology in human induced pluripotent stem cell-derived tissues.

Biography

  • Postdoctoral Fellow, Whitehead Institute/MIT, 2013-2020
  • Ph.D., University of Cambridge, 2012
  • B.S., Stanford University, 2008

Selected Publications

  1. Yang LG, March ZM, Stephenson RA, Narayan PS. Apolipoprotein E in lipid metabolism and neurodegenerative disease. Trends Endocrinol Metab. 2023;34(8):430-445.
  2. Screven LA, Pantazis CB, Andersh KM, Hong S, Vitale D, Lara E, Ku RY, Heutink P, Meyer J, Faber K, Nho K, Saykin AJ, Foroud TM, Nalls MA, Blauwendraat C, Singleton A, Narayan PS. Harnessing diversity to study Alzheimer's disease: A new iPSC resource from the NIH CARD and ADNI. Neuron. 2024;112(5):694-697.
  3. Sienski G, Narayan P, Bonner JM, Kory N, Boland S, Arczewska AA, Ralvenius WT, Akay L, Lockshin E, He L, Milo B, Graziosi A, Baru V, Lewis CA, Kellis M, Sabatini DM, Tsai LH, Lindquist S. APOE4 disrupts intracellular lipid homeostasis in human iPSC-derived glia. Sci Transl Med. 2021;13(583).
  4. Narayan P, Sienski G, Bonner JM, Lin YT, Seo J, Baru V, Haque A, Milo B, Akay LA, Graziosi A, Freyzon Y, Landgraf D, Hesse WR, Valastyan J, Barrasa MI, Tsai LH, Lindquist S. PICALM Rescues Endocytic Defects Caused by the Alzheimer's Disease Risk Factor APOE4. Cell Rep. 2020;33(1):108224.

Related Scientific Focus Areas

This page was last updated on Wednesday, March 27, 2024