Prashant Chittiboina, M.D.
Assistant Clinical Investigator
Neurosurgery Unit for Pituitary and Inheritable Diseases
Building 10, Room 3D20
10 Center Dr
The emphasis of my unit is translational research that addresses challenging clinical problems through the use of imaging and laboratory techniques. My unit is pursuing efforts to improve imaging of currently MRI- invisible pituitary tumors with novel intraoperative MRI, FDG-PET and near-infrared imaging. This research is supported by laboratory work to better understand the metabolism of pituitary tumors. Investigations into MRI findings in Neurofibromatosis 2 are leading to new surgical modalities for management of hearing loss from small vestibular schwannomas. Recent findings from DOTATATE-PET findings in VHL hemangioblastomas are also leading to exciting clinical trials in the management of hemangioblastomas.
Asuzu D, Chatain GP, Hayes C, Benzo S, McGlotten R, Keil M, Beri A, Sharma ST, Nieman L, Lodish M, Stratakis C, Lonser RR, Oldfield EH, Chittiboina P. Normalized Early Postoperative Cortisol and ACTH Values Predict Nonremission After Surgery for Cushing Disease. J Clin Endocrinol Metab. 2017;102(7):2179-2187.
Lu J, Chatain GP, Bugarini A, Wang X, Maric D, Walbridge S, Zhuang Z, Chittiboina P. Histone Deacetylase Inhibitor SAHA Is a Promising Treatment of Cushing Disease. J Clin Endocrinol Metab. 2017;102(8):2825-2835.
Chittiboina P, Talagala SL, Merkle H, Sarlls JE, Montgomery BK, Piazza MG, Scott G, Ray-Chaudhury A, Lonser RR, Oldfield EH, Koretsky AP, Butman JA. Endosphenoidal coil for intraoperative magnetic resonance imaging of the pituitary gland during transsphenoidal surgery. J Neurosurg. 2016;125(6):1451-1459.
Boyle J, Patronas NJ, Smirniotopoulos J, Herscovitch P, Dieckman W, Millo C, Maric D, Chatain GP, Hayes CP, Benzo S, Scott G, Edwards N, Ray Chaudhury A, Lodish MB, Sharma S, Nieman LK, Stratakis CA, Lonser RR, Chittiboina P. CRH stimulation improves <sup>18</sup>F-FDG-PET detection of pituitary adenomas in Cushing's disease. Endocrine. 2019;65(1):155-165.
Lu J, Montgomery BK, Chatain GP, Bugarini A, Zhang Q, Wang X, Edwards NA, Ray-Chaudhury A, Merrill MJ, Lonser RR, Chittiboina P. Corticotropin releasing hormone can selectively stimulate glucose uptake in corticotropinoma via glucose transporter 1. Mol Cell Endocrinol. 2018;470:105-114.
Related Scientific Focus Areas
Molecular Biology and Biochemistry
Genetics and Genomics
This page was last updated on September 2nd, 2020