Ping Zhang, Ph.D.

Stadtman Investigator

Structural Biophysics Laboratory

NCI/CCR

Advanced Technology Research Facility (ATRF), Room B2230
Frederick, MD 21701

301-228-4092

ping.zhang@nih.gov

Research Topics

My laboratory studies the structural and mechanistic basis of kinases that are closely related to human cancers. We apply interdisciplinary approaches spanning many fields such as cryoEM, X-ray crystallography, solution methods, biochemistry, cell signaling and post-translational modification, etc. We aim to combine structural and functional studies to reveal the molecular mechanism of kinase complexes' dysfunction and help develop novel reagents that may eventually lead to a cure for cancer and other diseases.

Biography

Dr. Zhang received her Ph.D. training in Dr. Michael Rossmann’s lab at Purdue University in the field of biochemistry and structural virology.  Her Ph.D. project was resolving the structures of poliovirus-receptor complexes using X-ray crystallography and cryo-electron microscopy (cryo-EM).  She completed her postdoctoral training in Dr. Susan Taylor’s laboratory at UCSD, working on a signal transduction system related to human diseases and learning other techniques in structural biology and cell signaling that are suited for studying dynamic signaling complexes. She joined the Structural Biophysics Laboratory at NCI as a Stadtman Tenure Track Investigator in August 2016.

Selected Publications

  1. Zhang P, Ye F, Bastidas AC, Kornev AP, Wu J, Ginsberg MH, Taylor SS. An Isoform-Specific Myristylation Switch Targets Type II PKA Holoenzymes to Membranes. Structure. 2015;23(9):1563-72.

  2. Zhang P, Knape MJ, Ahuja LG, Keshwani MM, King CC, Sastri M, Herberg FW, Taylor SS. Single Turnover Autophosphorylation Cycle of the PKA RIIβ Holoenzyme. PLoS Biol. 2015;13(7):e1002192.

  3. Taylor SS, Ilouz R, Zhang P, Kornev AP. Assembly of allosteric macromolecular switches: lessons from PKA. Nat Rev Mol Cell Biol. 2012;13(10):646-58.

  4. Zhang P, Smith-Nguyen EV, Keshwani MM, Deal MS, Kornev AP, Taylor SS. Structure and allostery of the PKA RIIβ tetrameric holoenzyme. Science. 2012;335(6069):712-6.

  5. Zhang P, Mueller S, Morais MC, Bator CM, Bowman VD, Hafenstein S, Wimmer E, Rossmann MG. Crystal structure of CD155 and electron microscopic studies of its complexes with polioviruses. Proc Natl Acad Sci U S A. 2008;105(47):18284-9.


This page was last updated on June 15th, 2017