Peter Williamson, M.D., Ph.D.

Senior Investigator

Translational Mycology Section

NIAID/DIR

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Building 10, Room 11C208
10 Center Drive
Bethesda, MD 20892

301-443-8339

peter.williamson2@nih.gov

Research Topics

The Translational Mycology Section seeks to understand the role of host-pathogen genetics in the outcome of human fungal infections. We use an array of methods from fungal genetics, cell biology, immunology, and population genetics to key aspects of the host-pathogen interface that might facilitate personalized therapeutic interventions.

The laboratory currently focuses on the neurotropic pathogen Cryptococcus which is a major cause of mortality in AIDS as well as in solid-organ transplant recipients and previously healthy individuals. Candida albicans is a major cause of bloodstream infections in the United States.

Biography

Dr. Williamson received his M.D./Ph.D. from Boston University in 1987 and completed a residency in internal medicine at Georgetown University before coming to the National Institutes of Health (NIH) for a fellowship in infectious diseases. In 1995, after serving a short stint as chief medical officer, Lalmba Sudan, Dr. Williamson joined the faculty at the University of Illinois at Chicago as an assistant professor of medicine in the section of infectious diseases. After progressing to the rank of professor of medicine, pathology, microbiology, and immunology, Dr. Williamson then returned to NIH to head the Translational Mycology Section in the Laboratory of Clinical Infectious Diseases.

Selected Publications

  1. Anjum S, Dean O, Kosa P, Magone MT, King KA, Fitzgibbon E, Kim HJ, Zalewski C, Murphy E, Billioux BJ, Chisholm J, Brewer CC, Krieger C, Elsegeiny W, Scott TL, Wang J, Hunsberger S, Bennett JE, Nath A, Marr KA, Bielekova B, Wendler D, Hammoud DA, Williamson P. Outcomes in Previously Healthy Cryptococcal Meningoencephalitis Patients Treated With Pulse Taper Corticosteroids for Post-infectious Inflammatory Syndrome. Clin Infect Dis. 2021;73(9):e2789-e2798.
  2. Hu G, Hacham M, Waterman SR, Panepinto J, Shin S, Liu X, Gibbons J, Valyi-Nagy T, Obara K, Jaffe HA, Ohsumi Y, Williamson PR. PI3K signaling of autophagy is required for starvation tolerance and virulenceof Cryptococcus neoformans. J Clin Invest. 2008;118(3):1186-97.
  3. Hu G, McQuiston T, Bernard A, Park YD, Qiu J, Vural A, Zhang N, Waterman SR, Blewett NH, Myers TG, Maraia RJ, Kehrl JH, Uzel G, Klionsky DJ, Williamson PR. A conserved mechanism of TOR-dependent RCK-mediated mRNA degradation regulates autophagy. Nat Cell Biol. 2015;17(7):930-942.
  4. Williamson PR, Jarvis JN, Panackal AA, Fisher MC, Molloy SF, Loyse A, Harrison TS. Cryptococcal meningitis: epidemiology, immunology, diagnosis and therapy. Nat Rev Neurol. 2017;13(1):13-24.
  5. Lu R, Hollingsworth C, Qiu J, Wang A, Hughes E, Xin X, Konrath KM, Elsegeiny W, Park YD, Atakulu L, Craft JC, Tramont EC, Mannino R, Williamson PR. Efficacy of Oral Encochleated Amphotericin B in a Mouse Model of Cryptococcal Meningoencephalitis. mBio. 2019;10(3).

Related Scientific Focus Areas

This page was last updated on Wednesday, February 7, 2024