Paule V. Joseph, Ph.D., M.S., FNP-BC, R.N., CTN-B

Lasker Clinical Research Scholar

Sensory Science and Metabolism Unit

NINR

Building 60 Room 268
1 Cloister Court
Bethesda, MD 20814

301-827-5234

paule.joseph@nih.gov

Research Topics

Topic: The Joseph’s lab investigates the complexity of the interplay of biological and behavioral components in addressing symptoms and managing medical problems relevant to nursing science, with a special emphasis on metabolic disorders like obesity and diabetes. The main focus of the laboratory is to understand the role of sensory science in metabolic disorders and use this information towards the development of novel treatments. Furthermore, the laboratory is interested in the interplay between metabolic disorders, sensory-related pathways and brain diseases, in particular alcohol and substance use disorders.

Issue: Each year, over 200,000 people visit a medical provider for chemosensory problems such as taste and smell disorders. When smell-taste perception is distorted and poorly treated, altered eating may still occur thus worsening health outcomes.

Impact: Dr. Joseph and her group are conducting pre-clinical, clinical and translational studies that aims to improve the diagnosis, prevention, and management of chemosensory disorders and symptoms. Dr. Joseph’s laboratory is leading research that is aimed at enhancing the understanding of molecular, cellular, neural, and behavioral mechanisms underlying symptoms to identify new targets for treatment and improve symptom management strategies. As a nurse and family nurse practitioner, Dr. Paule Joseph has worked extensively with individuals with diabetes and obesity, individuals undergoing weight loss surgery and alcohol and substance use disorders. Dr. Joseph brings a unique and necessary perspective to the study of chemosensory symptoms (taste and smell alterations) by incorporating both clinical and bench science approaches to unite three fields of science: nursing, sensory biology, and omics.

Selected Publications

  1. Joseph PV, Davidson HR, Boulineaux CM, Fourie NH, Franks AT, Abey SK, Henderson WA. Eating Behavior, Stress, and Adiposity: Discordance Between Perception and Physiology. Biol Res Nurs. 2018;20(5):531-540.

  2. Joseph PV, Wang Y, Fourie NH, Henderson WA. A computational framework for predicting obesity risk based on optimizing and integrating genetic risk score and gene expression profiles. PLoS One. 2018;13(5):e0197843.

  3. Joseph PV, Jaime-Lara RB, Wang Y, Xiang L, Henderson WA. Comprehensive and Systematic Analysis of Gene Expression Patterns Associated with Body Mass Index. Sci Rep. 2019;9(1):7447.

  4. Joseph PV, Abey SK, Wang D, Fourie NH, Kenea ND, Vishnyakova TG, Robinson JM, Weaver KR, Boulineaux CM, Davidson HR, Sherwin LB, Ozoji O, Diallo AF, Smyser PA, Patterson AP, Henderson WA. Colon Epithelial MicroRNA Network in Fatty Liver. Can J Gastroenterol Hepatol. 2018;2018:8246103.

  5. Hall KD, Ayuketah A, Brychta R, Cai H, Cassimatis T, Chen KY, Chung ST, Costa E, Courville A, Darcey V, Fletcher LA, Forde CG, Gharib AM, Guo J, Howard R, Joseph PV, McGehee S, Ouwerkerk R, Raisinger K, Rozga I, Stagliano M, Walter M, Walter PJ, Yang S, Zhou M. Ultra-Processed Diets Cause Excess Calorie Intake and Weight Gain: An Inpatient Randomized Controlled Trial of Ad Libitum Food Intake. Cell Metab. 2019;30(1):226.


This page was last updated on September 6th, 2019