Paneez Khoury, M.D., M.H.Sc., FAAAAI

Senior Clinician

Laboratory of Allergic Diseases


Building 10, Room 12C103
10 Center Drive
Bethesda, MD 20892


Research Topics

In the Human Eosinophil Section, Dr. Khoury is an investigator on protocols focused on eosinophilic disorders including hypereosinophilic syndromes (HES), overlap HES disorders such as EGPA, EGID, episodic angioedema with eosinophilia (EAE; Gleich’s syndrome), and eosinophilic fasciitis. Many of the protocols investigate novel therapeutic approaches to understanding the pathogenesis of these rare diseases. Dr. Khoury has a particular interest in treatment-refractory and difficult-to-treat HES and EGIDs. Dr. Khoury is a site-investigator for the Consortium of Eosinophilic Gastrointestinal Researchers (CEGIR) through NIH/NCATS/RDCRN and was awarded a Pilot Grant through the American Partnership for Eosinophilic Disorders (APFED) and CEGIR to investigate the prevalence and mechanisms of gastric dysfunction and motility abnormalities in eosinophilic gastritis.

Dr. Khoury is the director of the ACGME accredited fellowship training program in allergy immunology that enrolls four clinical trainees yearly. The program encompasses a dynamic training experience with broad exposure to the full range of allergic and immunologic diseases as well as a robust mentorship mission, faculty development, and innovative teaching methods.


Paneez Khoury, M.D. is a Senior Clinician in NIAID. She has been involved in translational research in eosinophilic disorders since joining the Human Eosinophil Section in 2012. She is the head of the Eosinophil Clinical Research Unit in the Human Eosinophil Section where she leads clinical investigative trials and studies in a variety of eosinophilic disorders. She received her M.D. from University of Illinois College of Medicine in Chicago, followed by an internal medicine residency at the Ohio State University and a fellowship in allergy and clinical immunology at NIH. She also holds a master's of health sciences from Duke University. She is board certified in internal medicine and allergy/immunology and is a fellow of the American Academy of Allergy, Asthma and Immunology (AAAAI).

At NIH, she serves as the chair of the Scientific Review Committee of the Laboratory of Parasitic Diseases and is the vice chair of the graduate medical education (GME) committee. Her external committee activities include serving as a chair of the core curriculum committee of the program directors assembly, and as a course director of the leadership institute of AAAAI.

Selected Publications

  1. Dellon ES, Khoury P, Muir AB, Liacouras CA, Safroneeva E, Atkins D, Collins MH, Gonsalves N, Falk GW, Spergel JM, Hirano I, Chehade M, Schoepfer AM, Menard-Katcher C, Katzka DA, Bonis PA, Bredenoord AJ, Geng B, Jensen ET, Pesek RD, Feuerstadt P, Gupta SK, Lucendo AJ, Genta RM, Hiremath G, McGowan EC, Moawad FJ, Peterson KA, Rothenberg ME, Straumann A, Furuta GT, Aceves SS. A Clinical Severity Index for Eosinophilic Esophagitis: Development, Consensus, and Future Directions. Gastroenterology. 2022;163(1):59-76.
  2. Dellon ES, Peterson KA, Murray JA, Falk GW, Gonsalves N, Chehade M, Genta RM, Leung J, Khoury P, Klion AD, Hazan S, Vaezi M, Bledsoe AC, Durrani SR, Wang C, Shaw C, Chang AT, Singh B, Kamboj AP, Rasmussen HS, Rothenberg ME, Hirano I. Anti-Siglec-8 Antibody for Eosinophilic Gastritis and Duodenitis. N Engl J Med. 2020;383(17):1624-1634.
  3. Khoury P, Abiodun AO, Holland-Thomas N, Fay MP, Klion AD. Hypereosinophilic Syndrome Subtype Predicts Responsiveness to Glucocorticoids. J Allergy Clin Immunol Pract. 2018;6(1):190-195.
  4. Wechsler ME, Akuthota P, Jayne D, Khoury P, Klion A, Langford CA, Merkel PA, Moosig F, Specks U, Cid MC, Luqmani R, Brown J, Mallett S, Philipson R, Yancey SW, Steinfeld J, Weller PF, Gleich GJ, EGPA Mepolizumab Study Team. Mepolizumab or Placebo for Eosinophilic Granulomatosis with Polyangiitis. N Engl J Med. 2017;376(20):1921-1932.
  5. Khoury P, Herold J, Alpaugh A, Dinerman E, Holland-Thomas N, Stoddard J, Gurprasad S, Maric I, Simakova O, Schwartz LB, Fong J, Lee CC, Xi L, Wang Z, Raffeld M, Klion AD. Episodic angioedema with eosinophilia (Gleich syndrome) is a multilineage cell cycling disorder. Haematologica. 2015;100(3):300-7.

Related Scientific Focus Areas

This page was last updated on Tuesday, February 13, 2024