Okihide Hikosaka, M.D., Ph.D.
NIH Distinguished Investigator
Neuronal Networks Section
Building 49, Room 2A50
49 Convent Drive
Bethesda, MD 20892-4435
One of our research projects is focused on the functions of the basal ganglia which seem to be involved in most of the above functions. Indeed, dysfunctions of the basal ganglia lead to various kinds of behavioral disorders which affect body movements, motivation, emotion, cognitive functions, goal-directed behavior, skill, and/or habit. We also study other brain areas that are connected with the basal ganglia: the cerebral cortical areas that provide the basal ganglia with sensorimotor-emotional signals; neuromodulatory systems (e.g., dopamine, serotonin), which may modulate the sensorimotor-emotional signals in the basal ganglia; and limbic systems (e.g., habenula), which may guide the neuromodulatory systems. We address these questions using behavioral, electrophysiological, and pharmacological methods.
Kim HF, Amita H, Hikosaka O. Indirect Pathway of Caudal Basal Ganglia for Rejection of Valueless Visual Objects. Neuron. 2017;94(4):920-930.e3.
Kim HF, Ghazizadeh A, Hikosaka O. Dopamine Neurons Encoding Long-Term Memory of Object Value for Habitual Behavior. Cell. 2015;163(5):1165-75.
Kim HF, Hikosaka O. Distinct basal ganglia circuits controlling behaviors guided by flexible and stable values. Neuron. 2013;79(5):1001-10.
Monosov IE, Hikosaka O. Selective and graded coding of reward uncertainty by neurons in the primate anterodorsal septal region. Nat Neurosci. 2013;16(6):756-62.
Matsumoto M, Hikosaka O. Two types of dopamine neuron distinctly convey positive and negative motivational signals. Nature. 2009;459(7248):837-41.
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This page was last updated on August 20th, 2018