Niki Moutsopoulos, D.D.S., Ph.D.

Investigator

Oral and Pharyngeal Cancer Branch/Oral Immunity and Inflammation Unit

NIDCR

Building 30, Room 327
30 Convent Drive
Bethesda, MD 20892

301-435-7182

nmoutsop@mail.nih.gov

Research Topics

Dr. Moutsopoulos is a dentist, specialized in periodontics and holding a Ph.D. in immunology. Her doctorate and post doctorate work has focused on immune-mediated pathologies that present in the oral cavity including Sjogrenös syndrome, periodontal disease and chronic wound healing. While these are distinct disease entities, they share as a salient feature non-resolving inflammation and immune mediated tissue destruction of which the mechanisms have been in the center of her research interest.  Activation of chronic inflammatory pathways in various disease entities have been linked to genetic susceptibility of the host, though emerging evidence implicates microbial factors for the initiation of disease pathogenesis for the majority of chronic inflammatory and autoimmune pathologies.

Dr. Moutsopoulos's program is focusing on host-microbial interactions that can drive chronic inflammatory responses and tissue destruction in the oral cavity. In her laboratory host-microbial interactions are interrogated through the use of in vitro culture systems and animal models, but her primary focus is on the study of immune-microbial interactions in humans. For this her laboratory is interrogating the oral microbiome and immune responses in the oral cavity in patient populations with oral inflammatory conditions.

Biography

Education:
  • 1998 - D.D.S., Aristotle University of Thessaloniki, Greece
  • 2003 - Certificate in Periodontics, Baltimore College of Dental Surgery, University of Maryland
  • 2006 - Ph.D., Department of Diagnostic Sciences and Pathology, Baltimore College of Dental Surgery, University of Maryland/National Institutes of Health
Brief Chronology of Employment:
  • 2004-2006 - Intramural Research Trainee Award (IRTA), NIDCR
  • 2006-2008 - Research Fellow, NIDCR
  • 2008-2010 - Clinical Fellow, NIDCR
  • 2007-Present - Adjunct Clinical Assistant Professor, Department of Periodontics, University of Maryland
  • 2010-Present - Assistant Clinical Investigator, NIDCR

Selected Publications

  1. Moutsopoulos NM, Zerbe CS, Wild T, Dutzan N, Brenchley L, DiPasquale G, Uzel G, Axelrod KC, Lisco A, Notarangelo LD, Hajishengallis G, Notarangelo LD, Holland SM. Interleukin-12 and Interleukin-23 Blockade in Leukocyte Adhesion Deficiency Type 1. N Engl J Med. 2017;376(12):1141-1146.

  2. Dutzan N, Konkel JE, Greenwell-Wild T, Moutsopoulos NM. Characterization of the human immune cell network at the gingival barrier. Mucosal Immunol. 2016;9(5):1163-1172.

  3. Moutsopoulos NM, Chalmers NI, Barb JJ, Abusleme L, Greenwell-Wild T, Dutzan N, Paster BJ, Munson PJ, Fine DH, Uzel G, Holland SM. Subgingival microbial communities in Leukocyte Adhesion Deficiency and their relationship with local immunopathology. PLoS Pathog. 2015;11(3):e1004698.

  4. Moutsopoulos NM, Konkel J, Sarmadi M, Eskan MA, Wild T, Dutzan N, Abusleme L, Zenobia C, Hosur KB, Abe T, Uzel G, Chen W, Chavakis T, Holland SM, Hajishengallis G. Defective neutrophil recruitment in leukocyte adhesion deficiency type I disease causes local IL-17-driven inflammatory bone loss. Sci Transl Med. 2014;6(229):229ra40.

  5. Dutzan N, Abusleme L, Bridgeman H, Greenwell-Wild T, Zangerle-Murray T, Fife ME, Bouladoux N, Linley H, Brenchley L, Wemyss K, Calderon G, Hong BY, Break TJ, Bowdish DM, Lionakis MS, Jones SA, Trinchieri G, Diaz PI, Belkaid Y, Konkel JE, Moutsopoulos NM. On-going Mechanical Damage from Mastication Drives Homeostatic Th17 Cell Responses at the Oral Barrier. Immunity. 2017;46(1):133-147.


This page was last updated on August 10th, 2017