Nihal Altan-Bonnet, Ph.D.

Senior Investigator

Host-Pathogen Dynamics

NHLBI

50 South Dr
Bethesda, MD 20814
United States

301-435-0817

nihal.altan-bonnet@nih.gov

Research Topics

Dr. Nihal Altan-Bonnet heads the Laboratory of Host-Pathogen Dynamics at the National Institutes of Health in the USA. Her lab is comprised of a multidisciplinary team of cell biologists, virologists, environmental engineers, and computational biologists who apply their talents to understand how viruses transmit themselves effectively among hosts and establish successful infections. Dr. Altan-Bonnet and her team have made groundbreaking discoveries that include:

Biography

Dr. Nihal Altan-Bonnet received her Ph.D. in cellular biophysics from The Rockefeller University. After conducting postdoctoral research with Dr. Jennifer Lippincott-Schwartz at the NIH, she joined the faculty of Rutgers University. In 2013, Dr. Altan-Bonnet returned to the NIH as an Earl Stadtman Investigator, becoming head of the Laboratory of Host-Pathogen Dynamics at the NHLBI and was promoted to tenured Senior Investigator in 2017.

Dr. Altan-Bonnet has been recognized several times for her outstanding research, including receiving the Presidential Early Career Award in Science and Engineering (PECASE) (2012), being named a Kavli Fellow of the National Academy of Sciences (2013), a Scialog Fellow of the Gordon and Betty Moore Foundation (2015-2017) and being elected to the American Academy of Microbiology (2022) and the Henry Kunkel Society (2023).

Selected Publications

  1. Ghosh S, Kumar M, Santiana M, Mishra A, Zhang M, Labayo H, Chibly AM, Nakamura H, Tanaka T, Henderson W, Lewis E, Voss O, Su Y, Belkaid Y, Chiorini JA, Hoffman MP, Altan-Bonnet N. Enteric viruses replicate in salivary glands and infect through saliva. Nature. 2022;607(7918):345-350.
  2. Ghosh S, Dellibovi-Ragheb TA, Kerviel A, Pak E, Qiu Q, Fisher M, Takvorian PM, Bleck C, Hsu VW, Fehr AR, Perlman S, Achar SR, Straus MR, Whittaker GR, de Haan CAM, Kehrl J, Altan-Bonnet G, Altan-Bonnet N. β-Coronaviruses Use Lysosomes for Egress Instead of the Biosynthetic Secretory Pathway. Cell. 2020;183(6):1520-1535.e14.
  3. Santiana M, Ghosh S, Ho BA, Rajasekaran V, Du WL, Mutsafi Y, De Jésus-Diaz DA, Sosnovtsev SV, Levenson EA, Parra GI, Takvorian PM, Cali A, Bleck C, Vlasova AN, Saif LJ, Patton JT, Lopalco P, Corcelli A, Green KY, Altan-Bonnet N. Vesicle-Cloaked Virus Clusters Are Optimal Units for Inter-organismal Viral Transmission. Cell Host Microbe. 2018;24(2):208-220.e8.
  4. Chen YH, Du W, Hagemeijer MC, Takvorian PM, Pau C, Cali A, Brantner CA, Stempinski ES, Connelly PS, Ma HC, Jiang P, Wimmer E, Altan-Bonnet G, Altan-Bonnet N. Phosphatidylserine vesicles enable efficient en bloc transmission of enteroviruses. Cell. 2015;160(4):619-630.
  5. Hsu NY, Ilnytska O, Belov G, Santiana M, Chen YH, Takvorian PM, Pau C, van der Schaar H, Kaushik-Basu N, Balla T, Cameron CE, Ehrenfeld E, van Kuppeveld FJ, Altan-Bonnet N. Viral reorganization of the secretory pathway generates distinct organelles for RNA replication. Cell. 2010;141(5):799-811.

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This page was last updated on Monday, April 1, 2024