Natalie Porat-Shliom, Ph.D.
Thoracic and GI Malignancies Branch
Building 10, Room 12C207 MSC 1919
Bethesda, MD 20892
Cells must rewire their metabolic programs to satisfy energy demands of growth and proliferation. The mitochondria confer this flexibility including alterations in fuel utilization, bioenergetics, and cell death susceptibility. Transformed cells exploit this plasticity to survive in adverse environmental conditions such as nutrient and/or oxygen deprivation and during chemotherapy. The general theme of the Porat-Shliom lab is to understand how normal and malignant cells metabolically adapt to changes in nutrient availability and energy demand. Towards this goal, we combine light microscopy approaches, particularly intravital microscopy and mouse genetics to study mitochondrial structure and function in intact tissues with a specific focus on the liver. These studies offer insights into basic biological mechanisms, their implications in cellular transformation and provide the foundation for novel diagnostic and clinical applications in cancer research.
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Dr. Porat-Shliom received her B.Sc. in biology, M.Sc. in neurobiology and Ph.D. in cell biology from Tel-Aviv University, Israel. Her Ph.D. research was performed at the NIH, through the Graduate Partnerships Program, under the supervision of Prof. Yoel Kloog (Tel Aviv University) and Dr. Julie Donaldson (NHLBI, NIH). For her postdoctoral training, Dr. Porat-Shliom joined the laboratory of Dr. Roberto Weigert (NCI, NIH) where she specialized in intravital microscopy studying mitochondria in the salivary gland for which she received the NIH Pathway to independence Award (K99/R00). In 2018, Dr. Porat-Shliom joined as a Tenure Track Investigator.
Meyer K, Ostrenko O, Bourantas G, Morales-Navarrete H, Porat-Shliom N, Segovia-Miranda F, Nonaka H, Ghaemi A, Verbavatz JM, Brusch L, Sbalzarini I, Kalaidzidis Y, Weigert R, Zerial M. A Predictive 3D Multi-Scale Model of Biliary Fluid Dynamics in the Liver Lobule. Cell Syst. 2017;4(3):277-290.e9.
Porat-Shliom N, Chen Y, Tora M, Shitara A, Masedunskas A, Weigert R. In vivo tissue-wide synchronization of mitochondrial metabolic oscillations. Cell Rep. 2014;9(2):514-21.
Masedunskas A, Porat-Shliom N, Tora M, Milberg O, Weigert R. Intravital microscopy for imaging subcellular structures in live mice expressing fluorescent proteins. J Vis Exp. 2013;(79).
Donaldson JG, Porat-Shliom N, Cohen LA. Clathrin-independent endocytosis: a unique platform for cell signaling and PM remodeling. Cell Signal. 2009;21(1):1-6.
Eyster CA, Higginson JD, Huebner R, Porat-Shliom N, Weigert R, Wu WW, Shen RF, Donaldson JG. Discovery of new cargo proteins that enter cells through clathrin-independent endocytosis. Traffic. 2009;10(5):590-9.
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This page was last updated on October 25th, 2019