Myriam Gorospe, Ph.D.

Senior Investigator

Laboratory of Genetics and Genomics

NIA

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251 Bayview Boulevard
Suite 100
Baltimore, MD 21224

410-558-8443

gorospem@mail.nih.gov

Research Topics

RNA-binding proteins and noncoding RNAs critically influence gene expression programs in physiology and disease. Towards the long-term goal of uncovering post-transcriptional regulatory mechanisms in aging, we use primary cells and immortal lines to study specific RNA-driven processes that control (1) cell division and senescence, (2) cellular adaptations to energy sensing, storage, and usage, (3) cell damage responses, and (4) neurodegeneration.

Biography

Dr. Gorospe received her Ph.D. in Cell and Developmental Biology from the State University of New York at Albany in 1993. She then joined the National Institute on Aging (NIA) for post-doctoral training and has been a Principal Investigator and head of the RNA Regulation Section since 1998. Her group studies post-transcriptional gene regulation by RNA-binding proteins and noncoding RNAs in mammalian cell models of stress response, senescence, energy metabolism, and neurodegeneration. Her team’s long-term goal is to identify RNA-driven gene expression programs in aging physiology and disease.

Selected Publications

  1. Chen CW, Papadopoli D, Szkop KJ, Guan BJ, Alzahrani M, Wu J, Jobava R, Asraf MM, Krokowski D, Vourekas A, Merrick WC, Komar AA, Koromilas AE, Gorospe M, Payea MJ, Wang F, Clayton BLL, Tesar PJ, Schaffer A, Miron A, Bederman I, Jankowsky E, Vogel C, Valášek LS, Dinman JD, Zhang Y, Tirosh B, Larsson O, Topisirovic I, Hatzoglou M. Plasticity of the mammalian integrated stress response. Nature. 2025;641(8065):1319-1328.
  2. Anerillas C, Altés G, Gresova K, Tsitsipatis D, Mazan-Mamczarz K, Banarjee R, Cunningham ASG, Salamini-Montemurri M, Yang JH, Munk R, Rossi M, Piao Y, Olinger B, Strassheim Q, Martindale JL, Fan J, Cui CY, De S, Rutherford DV, Hao Y, Li Z, Roberts J, Qi YA, Abdelmohsen K, de Cabo R, Herman AB, Maragkakis M, Basisty N, Gorospe M. SenCat: Cataloging human cell senescence through multi-omic profiling of multiple senescent primary cell types. Mol Cell. 2026;86(13):2605-2616.e8.
  3. Mazan-Mamczarz K, Tsitsipatis D, Childs BG, Carr AE, Dos Santos CR, Anerillas C, Romero B, Gregg JM, Henry-Smith C, Okereke AN, Michel M, Munk R, Martindale JL, Piao Y, Fan J, Hernandez MO, Kedei N, Viacheslavov ML, Wong MMF, Fedorova OV, Batish M, De S, Baker DJ, Gorospe M, Herman AB. Single-cell and spatial transcriptomics map senescent vascular cells in arterial remodeling during atherosclerosis in mice. Nat Aging. 2025;5(8):1528-1547.
  4. Anerillas C, Mazan-Mamczarz K, Herman AB, Munk R, Lam KG, Calvo-Rubio M, Garrido A, Tsitsipatis D, Martindale JL, Altés G, Rossi M, Piao Y, Fan J, Cui CY, De S, Abdelmohsen K, de Cabo R, Gorospe M. The YAP-TEAD complex promotes senescent cell survival by lowering endoplasmic reticulum stress. Nat Aging. 2023;3(10):1237-1250.
  5. Steri M, Orrù V, Idda ML, Pitzalis M, Pala M, Zara I, Sidore C, Faà V, Floris M, Deiana M, Asunis I, Porcu E, Mulas A, Piras MG, Lobina M, Lai S, Marongiu M, Serra V, Marongiu M, Sole G, Busonero F, Maschio A, Cusano R, Cuccuru G, Deidda F, Poddie F, Farina G, Dei M, Virdis F, Olla S, Satta MA, Pani M, Delitala A, Cocco E, Frau J, Coghe G, Lorefice L, Fenu G, Ferrigno P, Ban M, Barizzone N, Leone M, Guerini FR, Piga M, Firinu D, Kockum I, Lima Bomfim I, Olsson T, Alfredsson L, Suarez A, Carreira PE, Castillo-Palma MJ, Marcus JH, Congia M, Angius A, Melis M, Gonzalez A, Alarcón Riquelme ME, da Silva BM, Marchini M, Danieli MG, Del Giacco S, Mathieu A, Pani A, Montgomery SB, Rosati G, Hillert J, Sawcer S, D'Alfonso S, Todd JA, Novembre J, Abecasis GR, Whalen MB, Marrosu MG, Meloni A, Sanna S, Gorospe M, Schlessinger D, Fiorillo E, Zoledziewska M, Cucca F. Overexpression of the Cytokine BAFF and Autoimmunity Risk. N Engl J Med. 2017;376(17):1615-1626.

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This page was last updated on Thursday, August 20, 2026