Myriam Gorospe, Ph.D.
Laboratory of Genetics
251 Bayview Boulevard
Baltimore, MD 21224
RNA sequences modulate turnover and translation of mammalian mRNAs: RBPs and microRNAs associate dynamically with mRNAs and modulate their stability and translation rates. We use human diploid fibroblasts and immortal human cell lines to study specific mRNAs encoding proteins involved in cell division, cellular senescence, and the response to cellular damage (e.g., cdks, cyclins, cdk inhibitors, apoptosis-related proteins, oncoproteins, and tumor suppressors). We study the 5'-untranslated region (UTR), the coding region (CR) and the 3'UTR of mRNAs to identify sequences that affect mRNA half-life and translation, such as regions of association with RBPs and sequences of interaction with microRNAs.
Dr. Gorospe received her Ph.D. in Molecular and Developmental Biology from the State University of New York at Albany in 1993. She then joined the National Institute on Aging (NIA) for post-doctoral training and has been a Principal Investigator and head of the RNA Regulation Section since 1998. Her group studies post-transcriptional gene regulation in mammalian models of cellular stress, cell division, senescence, and aging. Her research program investigates the influence of RNA-binding proteins (RBPs) and microRNAs on the expression of gene products involved in these processes.
Kim KM, Noh JH, Bodogai M, Martindale JL, Pandey PR, Yang X, Biragyn A, Abdelmohsen K, Gorospe M. SCAMP4 enhances the senescent cell secretome. Genes Dev. 2018;32(13-14):909-914.
Zhang P, Kishimoto Y, Grammatikakis I, Gottimukkala K, Cutler RG, Zhang S, Abdelmohsen K, Bohr VA, Misra Sen J, Gorospe M, Mattson MP. Senolytic therapy alleviates Aβ-associated oligodendrocyte progenitor cell senescence and cognitive deficits in an Alzheimer's disease model. Nat Neurosci. 2019;22(5):719-728.
Kim KM, Noh JH, Bodogai M, Martindale JL, Yang X, Indig FE, Basu SK, Ohnuma K, Morimoto C, Johnson PF, Biragyn A, Abdelmohsen K, Gorospe M. Identification of senescent cell surface targetable protein DPP4. Genes Dev. 2017;31(15):1529-1534.
Yoon JH, De S, Srikantan S, Abdelmohsen K, Grammatikakis I, Kim J, Kim KM, Noh JH, White EJ, Martindale JL, Yang X, Kang MJ, Wood WH 3rd, Noren Hooten N, Evans MK, Becker KG, Tripathi V, Prasanth KV, Wilson GM, Tuschl T, Ingolia NT, Hafner M, Gorospe M. PAR-CLIP analysis uncovers AUF1 impact on target RNA fate and genome integrity. Nat Commun. 2014;5:5248.
Steri M, Orrù V, Idda ML, Pitzalis M, Pala M, Zara I, Sidore C, Faà V, Floris M, Deiana M, Asunis I, Porcu E, Mulas A, Piras MG, Lobina M, Lai S, Marongiu M, Serra V, Marongiu M, Sole G, Busonero F, Maschio A, Cusano R, Cuccuru G, Deidda F, Poddie F, Farina G, Dei M, Virdis F, Olla S, Satta MA, Pani M, Delitala A, Cocco E, Frau J, Coghe G, Lorefice L, Fenu G, Ferrigno P, Ban M, Barizzone N, Leone M, Guerini FR, Piga M, Firinu D, Kockum I, Lima Bomfim I, Olsson T, Alfredsson L, Suarez A, Carreira PE, Castillo-Palma MJ, Marcus JH, Congia M, Angius A, Melis M, Gonzalez A, Alarcón Riquelme ME, da Silva BM, Marchini M, Danieli MG, Del Giacco S, Mathieu A, Pani A, Montgomery SB, Rosati G, Hillert J, Sawcer S, D'Alfonso S, Todd JA, Novembre J, Abecasis GR, Whalen MB, Marrosu MG, Meloni A, Sanna S, Gorospe M, Schlessinger D, Fiorillo E, Zoledziewska M, Cucca F. Overexpression of the Cytokine BAFF and Autoimmunity Risk. N Engl J Med. 2017;376(17):1615-1626.
Related Scientific Focus Areas
Molecular Biology and Biochemistry
Genetics and Genomics
This page was last updated on August 31st, 2019