Myriam Gorospe, Ph.D.

Senior Investigator

Laboratory of Genetics and Genomics

NIA

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251 Bayview Boulevard
Suite 100
Baltimore, MD 21224

410-558-8443

gorospem@mail.nih.gov

Research Topics

RNA-binding proteins and noncoding RNAs critically influence gene expression programs in physiology and disease. Towards the long-term goal of uncovering post-transcriptional regulatory mechanisms in aging, we use primary cells and immortal lines to study specific RNA-driven processes that control (1) cell division and senescence, (2) cellular adaptations to energy sensing, storage, and usage, (3) cell damage responses, and (4) neurodegeneration.

Biography

Dr. Gorospe received her Ph.D. in Cell and Developmental Biology from the State University of New York at Albany in 1993. She then joined the National Institute on Aging (NIA) for post-doctoral training and has been a Principal Investigator and head of the RNA Regulation Section since 1998. Her group studies post-transcriptional gene regulation by RNA-binding proteins and noncoding RNAs in mammalian cell models of stress response, senescence, energy metabolism, and neurodegeneration. Her team’s long-term goal is to identify RNA-driven gene expression programs in aging physiology and disease.

Selected Publications

  1. Anerillas C, Mazan-Mamczarz K, Herman AB, Munk R, Lam KG, Calvo-Rubio M, Garrido A, Tsitsipatis D, Martindale JL, Altés G, Rossi M, Piao Y, Fan J, Cui CY, De S, Abdelmohsen K, de Cabo R, Gorospe M. The YAP-TEAD complex promotes senescent cell survival by lowering endoplasmic reticulum stress. Nat Aging. 2023;3(10):1237-1250.
  2. Zhang P, Kishimoto Y, Grammatikakis I, Gottimukkala K, Cutler RG, Zhang S, Abdelmohsen K, Bohr VA, Misra Sen J, Gorospe M, Mattson MP. Senolytic therapy alleviates Aβ-associated oligodendrocyte progenitor cell senescence and cognitive deficits in an Alzheimer's disease model. Nat Neurosci. 2019;22(5):719-728.
  3. Kim KM, Noh JH, Bodogai M, Martindale JL, Yang X, Indig FE, Basu SK, Ohnuma K, Morimoto C, Johnson PF, Biragyn A, Abdelmohsen K, Gorospe M. Identification of senescent cell surface targetable protein DPP4. Genes Dev. 2017;31(15):1529-1534.
  4. Herman AB, Tsitsipatis D, Anerillas C, Mazan-Mamczarz K, Carr AE, Gregg JM, Wang M, Zhang J, Michel M, Henry-Smith CA, Harris SC, Munk R, Martindale JL, Piao Y, Fan J, Mattison JA, De S, Abdelmohsen K, Maul RW, Tanaka T, Moore AZ, DeMouth ME, Sidoli S, Ferrucci L, Liu Y, de Cabo R, Lakatta EG, Gorospe M. DPP4 inhibition impairs senohemostasis to improve plaque stability in atherosclerotic mice. J Clin Invest. 2023;133(12).
  5. Steri M, Orrù V, Idda ML, Pitzalis M, Pala M, Zara I, Sidore C, Faà V, Floris M, Deiana M, Asunis I, Porcu E, Mulas A, Piras MG, Lobina M, Lai S, Marongiu M, Serra V, Marongiu M, Sole G, Busonero F, Maschio A, Cusano R, Cuccuru G, Deidda F, Poddie F, Farina G, Dei M, Virdis F, Olla S, Satta MA, Pani M, Delitala A, Cocco E, Frau J, Coghe G, Lorefice L, Fenu G, Ferrigno P, Ban M, Barizzone N, Leone M, Guerini FR, Piga M, Firinu D, Kockum I, Lima Bomfim I, Olsson T, Alfredsson L, Suarez A, Carreira PE, Castillo-Palma MJ, Marcus JH, Congia M, Angius A, Melis M, Gonzalez A, Alarcón Riquelme ME, da Silva BM, Marchini M, Danieli MG, Del Giacco S, Mathieu A, Pani A, Montgomery SB, Rosati G, Hillert J, Sawcer S, D'Alfonso S, Todd JA, Novembre J, Abecasis GR, Whalen MB, Marrosu MG, Meloni A, Sanna S, Gorospe M, Schlessinger D, Fiorillo E, Zoledziewska M, Cucca F. Overexpression of the Cytokine BAFF and Autoimmunity Risk. N Engl J Med. 2017;376(17):1615-1626.

Related Scientific Focus Areas

This page was last updated on Sunday, August 18, 2024