
Michele K. Evans, M.D.
Senior Investigator
Laboratory of Epidemiology and Population Sciences
NIA
Research Topics
The biologic and molecular pathways through which the health and longevity trajectories of individuals in American society are influenced are unknown currently. We conduct interdisciplinary clinical and basic science research focused on examining the underlying cause of the disproportionate incidence, morbidity, and mortality of age-related disease among various segments of the American population. The approach provides a two-way bridge between basic science laboratory studies and clinical research that spans from epidemiologic populations to the bench. The laboratory dissects the interaction of the exogenous and endogenous aspects of the exposome environmental exposure, biologic vulnerabilities, genetics, and social environment to garner insights into how these interactions result in disproportionate rates of age-related disease and disability. Our study, Healthy Aging in Neighborhoods of Diversity across the Life Span (HANDLS) provides a cohort for translational research studies to facilitate investigation of health disparities in terms of a medical/biologic phenotype that may be amenable to dissection by bench scientists examining the molecular aspects of aging, disease, and disability. The goal is to identify targets for translation or intervention to ameliorate health disparities.
Biography
Dr. Michele K. Evans, an internist and medical oncologist, received an undergraduate degree from Barnard College, Columbia University, and a medical degree from Rutgers, The State University of New Jersey, The Robert Wood Johnson Medical School in Piscataway. She received her postgraduate training in internal medicine at Emory University School of Medicine and fellowship training in medical oncology within the Medicine Branch of the Clinical Oncology Program at the National Cancer Institute (NCI). Dr. Evans serves as Deputy Scientific Director, NIA as well as the Training Director for the NIA Intramural Research Program. Trained as a physician scientist, she conducts epidemiologic clinical research in health disparities and basic bench research on the biology of health disparities and minority aging.
Selected Publications
- Lazo S, Noren Hooten N, Green J, Eitan E, Mode NA, Liu QR, Zonderman AB, Ezike N, Mattson MP, Ghosh P, Evans MK. Mitochondrial DNA in extracellular vesicles declines with age. Aging Cell. 2021;20(1):e13283.
- Byappanahalli AM, Omoniyi V, Noren Hooten N, Smith JT, Mode NA, Ezike N, Zonderman AB, Evans MK. Extracellular vesicle mitochondrial DNA levels are associated with race and mitochondrial DNA haplogroup. iScience. 2024;27(1):108724.
- Shen B, Mode NA, Noren Hooten N, Pacheco NL, Ezike N, Zonderman AB, Evans MK. Association of Race and Poverty Status With DNA Methylation-Based Age. JAMA Netw Open. 2023;6(4):e236340.
- Powe CE, Evans MK, Wenger J, Zonderman AB, Berg AH, Nalls M, Tamez H, Zhang D, Bhan I, Karumanchi SA, Powe NR, Thadhani R. Vitamin D-binding protein and vitamin D status of black Americans and white Americans. N Engl J Med. 2013;369(21):1991-2000.
- Freeman DW, Noren Hooten N, Eitan E, Green J, Mode NA, Bodogai M, Zhang Y, Lehrmann E, Zonderman AB, Biragyn A, Egan J, Becker KG, Mattson MP, Ejiogu N, Evans MK. Altered Extracellular Vesicle Concentration, Cargo, and Function in Diabetes. Diabetes. 2018;67(11):2377-2388.
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This page was last updated on Monday, September 14, 2026