Michele K. Evans, M.D.

Senior Investigator

Laboratory of Epidemiology and Population Science

NIA

251 Bayview Boulevard
Suite 100
Baltimore, MD 21224

410-558-8110

me42v@nih.gov

Research Topics

The biologic and molecular pathways through which the health and longevity trajectories of individuals in American society are influenced are unknown at this time. We conduct interdisciplinary clinical and basic science research focused on examining the underlying cause of the disproportionate incidence, morbidity, and mortality of age-related disease among minority and low socioeconomic status (SES) Americans. The approach provides a two-way bridge between basic science laboratory studies and clinical research that spans from the targeted epidemiologic population to the bench. Dissecting the interaction of race, socioeconomic status, culture, behavior, environmental exposure, biologic vulnerabilities, genetics, social environment, health care access, and quality of health care provides insight into how these interactions result in disproportionate rates of age-related disease and disability. Our study, Healthy Aging in Neighborhoods of Diversity across the Life Span (HANDLS) provides a cohort for translational research studies to facilitate investigation of health disparities in terms of a medical/biologic phenotype that may be amenable to dissection by bench scientists examining the molecular aspects of aging, disease and disability.

Biography

Dr. Michele K. Evans, an internist and medical oncologist, received an undergraduate degree from Barnard College, Columbia University and a medical degree from Rutgers, The State University of New Jersey, The Robert Wood Johnson Medical School in Piscataway. She received her postgraduate training in internal medicine at Emory University School of Medicine and fellowship training in medical oncology within the Medicine Branch of the Clinical Oncology Program at the National Cancer Institute (NCI). Dr. Evans serves as Deputy Scientific Director, NIA as well as the Training Director for the NIA Intramural Research program. Trained as a physician scientist, she conducts epidemiologic clinical research in health disparities and basic bench research on the biology of health disparities and minority aging.

Selected Publications

  1. Powe CE, Evans MK, Wenger J, Zonderman AB, Berg AH, Nalls M, Tamez H, Zhang D, Bhan I, Karumanchi SA, Powe NR, Thadhani R. Vitamin D-binding protein and vitamin D status of black Americans and white Americans. N Engl J Med. 2013;369(21):1991-2000.

  2. Freeman DW, Noren Hooten N, Eitan E, Green J, Mode NA, Bodogai M, Zhang Y, Lehrmann E, Zonderman AB, Biragyn A, Egan J, Becker KG, Mattson MP, Ejiogu N, Evans MK. Altered Extracellular Vesicle Concentration, Cargo, and Function in Diabetes. Diabetes. 2018;67(11):2377-2388.

  3. Beydoun MA, Shaked D, Tajuddin SM, Weiss J, Evans MK, Zonderman AB. Accelerated epigenetic age and cognitive decline among urban-dwelling adults. Neurology. 2020;94(6):e613-e625.

  4. Dluzen DF, Noren Hooten N, De S, Wood WH 3rd, Zhang Y, Becker KG, Zonderman AB, Tanaka T, Ferrucci L, Evans MK. Extracellular RNA profiles with human age. Aging Cell. 2018;17(4):e12785.

  5. Dluzen DF, Noren Hooten N, Zhang Y, Kim Y, Glover FE, Tajuddin SM, Jacob KD, Zonderman AB, Evans MK. Racial differences in microRNA and gene expression in hypertensive women. Sci Rep. 2016;6:35815.


This page was last updated on August 25th, 2020