Michael J. O'Donovan, M.D., Ph.D.
Developmental Neurobiology Section
Building 35, Room 3C-1014
35 Convent Drive
Bethesda, MD 20892-3700
Our current effort is focussed on understanding how motoneurons trigger and modulate the locomotor rhythm in the neonatal spinal cord. This involves several techniques including, whole cell patch clamping, calcium and voltage imaging, optogenetics and immunocytochemistry.
Falgairolle M, Puhl JG, Pujala A, Liu W, O'Donovan MJ. Motoneurons regulate the central pattern generator during drug-induced locomotor-like activity in the neonatal mouse. Elife. 2017;6.
Blivis D, Haspel G, Mannes PZ, O'Donovan MJ, Iadarola MJ. Identification of a novel spinal nociceptive-motor gate control for Aδ pain stimuli in rats. Elife. 2017;6.
Pujala A, Blivis D, O'Donovan MJ. Interactions between Dorsal and Ventral Root Stimulation on the Generation of Locomotor-Like Activity in the Neonatal Mouse Spinal Cord. eNeuro. 2016;3(3).
Falgairolle M, O'Donovan MJ. Pharmacological Investigation of Fluoro-Gold Entry into Spinal Neurons. PLoS One. 2015;10(6):e0131430.
Yoshida Y, Yoshimi R, Yoshii H, Kim D, Dey A, Xiong H, Munasinghe J, Yazawa I, O'Donovan MJ, Maximova OA, Sharma S, Zhu J, Wang H, Morse HC 3rd, Ozato K. The transcription factor IRF8 activates integrin-mediated TGF-β signaling and promotes neuroinflammation. Immunity. 2014;40(2):187-98.
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This page was last updated on June 21st, 2019