Michael J. Krashes, Ph.D.


Section on Motivational Processes Underlying Appetite, Diabetes, Endocrinology, and Obesity Branch


Building 10-CRC, Room 6-3932
10 Center Dr
Bethesda, MD 20814

+1 301 827 0960


Research Topics

The ultimate goal of my research is to decipher the wiring diagram that underlies hunger. To achieve this, we employ novel genetic tools and techniques to dissect conserved feeding circuits with the hopes of furthering our understanding of the behaviors that drive humans to obtain food and ultimately how these behaviors can be manipulated to battle human eating afflictions.


  • Ph.D., University of Massachusetts Medical School, 2009

Selected Publications

  1. Burnett CJ, Li C, Webber E, Tsaousidou E, Xue SY, BrĂ¼ning JC, Krashes MJ. Hunger-Driven Motivational State Competition. Neuron. 2016;92(1):187-201.

  2. Garfield AS, Li C, Madara JC, Shah BP, Webber E, Steger JS, Campbell JN, Gavrilova O, Lee CE, Olson DP, Elmquist JK, Tannous BA, Krashes MJ, Lowell BB. A neural basis for melanocortin-4 receptor-regulated appetite. Nat Neurosci. 2015;18(6):863-71.

  3. Garfield AS, Shah BP, Burgess CR, Li MM, Li C, Steger JS, Madara JC, Campbell JN, Kroeger D, Scammell TE, Tannous BA, Myers MG Jr, Andermann ML, Krashes MJ, Lowell BB. Dynamic GABAergic afferent modulation of AgRP neurons. Nat Neurosci. 2016;19(12):1628-1635.

  4. Vardy E, Robinson JE, Li C, Olsen RHJ, DiBerto JF, Giguere PM, Sassano FM, Huang XP, Zhu H, Urban DJ, White KL, Rittiner JE, Crowley NA, Pleil KE, Mazzone CM, Mosier PD, Song J, Kash TL, Malanga CJ, Krashes MJ, Roth BL. A New DREADD Facilitates the Multiplexed Chemogenetic Interrogation of Behavior. Neuron. 2015;86(4):936-946.

  5. Krashes MJ, DasGupta S, Vreede A, White B, Armstrong JD, Waddell S. A neural circuit mechanism integrating motivational state with memory expression in Drosophila. Cell. 2009;139(2):416-27.

Related Scientific Focus Areas

This page was last updated on April 11th, 2019