Matthew J. Memoli, M.D., M.S.

Senior Clinician

LID Clinical Studies Unit


Building 33, Room 3E13C.4
33 North Drive
Bethesda, MD 20892


Research Topics

The LID Clinical Studies Unit (CSU) seeks to perform translational research studies to answer fundamental questions regarding human influenza and other emerging viral infections to inform and impact future vaccine and therapeutic design, while also making an effort to assist in evaluation of novel products that may impact human health. With a focus on healthy volunteer research, the LID CSU has been able to continue their primary work on influenza while quickly able to respond to assist in research of emerging infections.

The LID CSU reinvigorated influenza healthy volunteer challenge studies in 2011 after a decade absence of these studies in the U.S. The 2009 H1N1 influenza challenge virus made by the LID CSU was the first under an FDA IND and the LID CSU influenza challenge model has become the primary focus of the group. The LID CSU continues to make new influenza challenge viruses, develop validated models, and serves as a worldwide leader in establishing methods and standards for performing influenza and other challenge studies. The LID CSU challenge studies have been instrumental in further elucidating human pathogenesis of influenza infections and identifying correlates of protection and predictors of severe disease.

In addition, in recent years the LID CSU has initiated efforts to perform uncommon and difficult, but necessary clinical studies for the purposes of evaluating novel vaccines and therapeutics particularly universal influenza vaccines in the human challenge model and extremely novel universal vaccines for vector borne disease like Dengue, Zika, and Leishmaniasis.

Translating science from bedside to bench and then back to the bedside in the form of a product that can prevent or treat an infection is an extremely important part of the development of future impactful vaccines and therapeutics. Studies such as those carried out by the LID CSU play a key role in this process that will lead to improved prevention and mitigation of epidemics, pandemics, and emerging infections.


Dr. Memoli is a graduate of the College of William and Mary and he received his Masters Degree in Microbiology from Thomas Jefferson University in Philadelphia, PA. He then received his MD from St George's University School of Medicine. He completed a residency in internal medicine at the Washington Hospital Center Georgetown University Internal Medicine Program in Washington, DC. After completing an infectious disease fellowship in NIAID at the National Institutes of Health, Dr. Memoli developed a clinical/translational research program to study influenza and other respiratory viruses in the Laboratory of Infectious Diseases. He now serves as the Chief of the LID Clinical Studies Unit.

Selected Publications

  1. Memoli MJ, Czajkowski L, Reed S, Athota R, Bristol T, Proudfoot K, Fargis S, Stein M, Dunfee RL, Shaw PA, Davey RT, Taubenberger JK. Validation of the wild-type influenza A human challenge model H1N1pdMIST: an A(H1N1)pdm09 dose-finding investigational new drug study. Clin Infect Dis. 2015;60(5):693-702.
  2. Han A, Czajkowski LM, Donaldson A, Baus HA, Reed SM, Athota RS, Bristol T, Rosas LA, Cervantes-Medina A, Taubenberger JK, Memoli MJ. A Dose-finding Study of a Wild-type Influenza A(H3N2) Virus in a Healthy Volunteer Human Challenge Model. Clin Infect Dis. 2019;69(12):2082-2090.
  3. Pleguezuelos O, James E, Fernandez A, Lopes V, Rosas LA, Cervantes-Medina A, Cleath J, Edwards K, Neitzey D, Gu W, Hunsberger S, Taubenberger JK, Stoloff G, Memoli MJ. Efficacy of FLU-v, a broad-spectrum influenza vaccine, in a randomized phase IIb human influenza challenge study. NPJ Vaccines. 2020;5(1):22.
  4. Manning JE, Oliveira F, Coutinho-Abreu IV, Herbert S, Meneses C, Kamhawi S, Baus HA, Han A, Czajkowski L, Rosas LA, Cervantes-Medina A, Athota R, Reed S, Mateja A, Hunsberger S, James E, Pleguezuelos O, Stoloff G, Valenzuela JG, Memoli MJ. Safety and immunogenicity of a mosquito saliva peptide-based vaccine: a randomised, placebo-controlled, double-blind, phase 1 trial. Lancet. 2020;395(10242):1998-2007.
  5. Han A, Czajkowski L, Rosas LA, Cervantes-Medina A, Xiao Y, Gouzoulis M, Lumbard K, Hunsberger S, Reed S, Athota R, Baus HA, Lwin A, Sadoff J, Taubenberger JK, Memoli MJ. Safety and Efficacy of CR6261 in an Influenza A H1N1 Healthy Human Challenge Model. Clin Infect Dis. 2021;73(11):e4260-e4268.

Related Scientific Focus Areas

This page was last updated on Wednesday, November 8, 2023