Mark Histed, Ph.D.


Unit on Neural Computation and Behavior (Histed group)


John Edward Porter Neuroscience Research Center (Building 35), Room 3A-1002
35 Convent Drive
Bethesda, MD 20814


Research Topics

A single sensory stimulus or motor action changes the activity of thousands or more neurons in the mammalian cerebral cortex. Dr. Histed’s group uses sensory behavior in the mouse, combined with in vivo electrophysiology, optogenetics, and two-photon imaging, to understand how the brain interprets the activity of many cells --- how the brain decodes neurons’ spikes to make decisions.


Dr. Histed received a Ph.D. from the Massachusetts Institute of Technology, where with Earl K. Miller he studied how frontal and basal ganglia neuronal activity underlies complex behaviors. He did postdoctoral work at Harvard and the University of Chicago, with R. Clay Reid and John H.R. Maunsell, studying how the cerebral cortex represents the sensory world and developing psychophysical methods to measure perceptual behavior in rodents. Dr. Histed joined NIMH as an principal investigator in 2016.

Selected Publications

  1. Goldbach HC, Akitake B, Leedy CE, Histed MH. Performance in even a simple perceptual task depends on mouse secondary visual areas. Elife. 2021;10.

  2. Sanzeni A, Akitake B, Goldbach HC, Leedy CE, Brunel N, Histed MH. Inhibition stabilization is a widespread property of cortical networks. Elife. 2020;9.

  3. Sanzeni A, Histed MH. Finding patterns in cortical responses. Elife. 2020;9.

  4. Sanzeni A, Histed MH, Brunel N. Response nonlinearities in networks of spiking neurons. PLoS Comput Biol. 2020;16(9):e1008165.

  5. Histed MH. Feedforward Inhibition Allows Input Summation to Vary in Recurrent Cortical Networks. eNeuro. 2018;5(1).

This page was last updated on August 17th, 2021