Maria T. Landi, M.D., Ph.D.

Senior Investigator

Integrative Tumor Epidemiology Branch


9609 Medical Center Drive
Room SG/7E106
Rockville, MD 20850


Research Topics

  • To study the genetic and environmental determinants of lung cancer using an integrative approach that allows the investigation of the process that begins with smoking initiation and persistence, continues with lung cancer development, and ends with progression to disseminated disease or response to therapy and survival.
  • To investigate the genetic and environmental determinants of cutaneous malignant melanoma in the general population and in high-risk families; in particular, to explore the relationship of genetic susceptibility, pigmentation, and other host factors in the etiology of melanoma.
  • To study lung and kidney tumor evolution and intra-tumor heterogeneity in relation to genetic susceptibility, exposures, and the tumor microenvironment integrating DNA and RNA sequencing and whole-genome methylation analyses.


Dr. Landi received an M.D. with honors from the University of Milan, Italy, and was trained in oncology and general medicine at the San Raffaele Hospital, University of Milan. She received a Ph.D. in occupational medicine and industrial hygiene, subgroup of molecular epidemiology, from an Italian University Consortium in 1993, and qualified for the associate professorship in occupational medicine and industrial hygiene in the Italian Universities in 1998. Dr. Landi received tenure at the Genetic Epidemiology Branch (GEB) in 2006. Dr. Landi is Associate Professor of Epidemiology at the Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.

Selected Publications

  1. Shi J, Chatterjee N, Rotunno M, Wang Y, Pesatori AC, Consonni D, Li P, Wheeler W, Broderick P, Henrion M, Eisen T, Wang Z, Chen W, Dong Q, Albanes D, Thun M, Spitz MR, Bertazzi PA, Caporaso NE, Chanock SJ, Amos CI, Houlston RS, Landi MT. Inherited variation at chromosome 12p13.33, including RAD52, influences the risk of squamous cell lung carcinoma. Cancer Discov. 2012;2(2):131-9.

  2. Shi J, Yang XR, Ballew B, Rotunno M, Calista D, Fargnoli MC, Ghiorzo P, Bressac-de Paillerets B, Nagore E, Avril MF, Caporaso NE, McMaster ML, Cullen M, Wang Z, Zhang X, NCI DCEG Cancer Sequencing Working Group., NCI DCEG Cancer Genomics Research Laboratory., French Familial Melanoma Study Group., Bruno W, Pastorino L, Queirolo P, Banuls-Roca J, Garcia-Casado Z, Vaysse A, Mohamdi H, Riazalhosseini Y, Foglio M, Jouenne F, Hua X, Hyland PL, Yin J, Vallabhaneni H, Chai W, Minghetti P, Pellegrini C, Ravichandran S, Eggermont A, Lathrop M, Peris K, Scarra GB, Landi G, Savage SA, Sampson JN, He J, Yeager M, Goldin LR, Demenais F, Chanock SJ, Tucker MA, Goldstein AM, Liu Y, Landi MT. Rare missense variants in POT1 predispose to familial cutaneous malignant melanoma. Nat Genet. 2014;46(5):482-6.

  3. Shi J, Marconett CN, Duan J, Hyland PL, Li P, Wang Z, Wheeler W, Zhou B, Campan M, Lee DS, Huang J, Zhou W, Triche T, Amundadottir L, Warner A, Hutchinson A, Chen PH, Chung BS, Pesatori AC, Consonni D, Bertazzi PA, Bergen AW, Freedman M, Siegmund KD, Berman BP, Borok Z, Chatterjee N, Tucker MA, Caporaso NE, Chanock SJ, Laird-Offringa IA, Landi MT. Characterizing the genetic basis of methylome diversity in histologically normal human lung tissue. Nat Commun. 2014;5:3365.

  4. Consonni D, Pierobon M, Gail MH, Rubagotti M, Rotunno M, Goldstein A, Goldin L, Lubin J, Wacholder S, Caporaso NE, Bertazzi PA, Tucker MA, Pesatori AC, Landi MT. Lung cancer prognosis before and after recurrence in a population-based setting. J Natl Cancer Inst. 2015;107(6):djv059.

  5. Hua X, Zhao W, Pesatori AC, Consonni D, Caporaso NE, Zhang T, Zhu B, Wang M, Jones K, Hicks B, Song L, Sampson J, Wedge DC, Shi J, Landi MT. Genetic and epigenetic intratumor heterogeneity impacts prognosis of lung adenocarcinoma. Nat Commun. 2020;11(1):2459.

This page was last updated on October 20th, 2020