Marcos Morgan, Ph.D.
Reproductive & Developmental Biology Laboratory/Male Reproduction & RNA Biology Group
Morgan’s group seeks to understand the role of post-transcriptional gene regulation during germline development. Normal tissue development depends on RNA binding proteins and non-coding RNAs; however, more recently, modifications to the RNAs have also been shown to be critical in this process. Dysregulation of gene expression at the post-transcriptional level leads to growth defects and cancer.
Group members study non-templated addition of nucleotides to the 3' end of RNAs, a critical type of post-transcriptional modification. These 3' additions of nucleotides are catalyzed by enzymes known as terminal nucleotidyl transferases (TENTs). By systematically studying TENTs using animal models and advanced molecular biology techniques, Morgan and his group will begin to understand the physiological relevance of terminal modifications in tissue development. Their ultimate goal is to bridge the gap between the mechanistic knowledge of gene regulation at the cellular level and the principles that define multicellular organization.
Morgan graduated from the University of Buenos Aires in 2005 with a degree in biology and completed a doctorate in molecular biology in 2011. For his postdoctoral studies, he held a joint appointment at the European Molecular Biology Laboratory (EMBL) in Italy and the European Bioinformatics Institute (EBI) in the United Kingdom. During the final years of his postdoctoral fellowship, he joined the MRC Centre for Regenerative Medicine in Edinburgh, Scotland. Morgan joined NIEHS as an NIH Stadtman Tenure-Track Investigator June 2019.
- Morgan M, Kumar L, Li Y, Baptissart M. Post-transcriptional regulation in spermatogenesis: all RNA pathways lead to healthy sperm. Cell Mol Life Sci. 2021;78(24):8049-8071.
- Paris J, Morgan M, Campos J, Spencer GJ, Shmakova A, Ivanova I, Mapperley C, Lawson H, Wotherspoon DA, Sepulveda C, Vukovic M, Allen L, Sarapuu A, Tavosanis A, Guitart AV, Villacreces A, Much C, Choe J, Azar A, van de Lagemaat LN, Vernimmen D, Nehme A, Mazurier F, Somervaille TCP, Gregory RI, O'Carroll D, Kranc KR. Targeting the RNA m(6)A Reader YTHDF2 Selectively Compromises Cancer Stem Cells in Acute Myeloid Leukemia. Cell Stem Cell. 2019;25(1):137-148.e6.
- Morgan M, Kabayama Y, Much C, Ivanova I, Di Giacomo M, Auchynnikava T, Monahan JM, Vitsios DM, Vasiliauskaitė L, Comazzetto S, Rappsilber J, Allshire RC, Porse BT, Enright AJ, O'Carroll D. A programmed wave of uridylation-primed mRNA degradation is essential for meiotic progression and mammalian spermatogenesis. Cell Res. 2019;29(3):221-232.
- Gupta A, Li Y, Chen SH, Papas BN, Martin NP, Morgan M. TUT4/7-mediated uridylation of a coronavirus subgenomic RNAs delays viral replication. Commun Biol. 2023;6(1):438.
Related Scientific Focus Areas
Genetics and Genomics
This page was last updated on Tuesday, August 22, 2023