Marc L. Reitman, M.D., Ph.D.
Diabetes, Endocrinology, and Obesity Branch
Building 10-CRC, Room 5-5940
10 Center Drive
Bethesda, MD 20814
Obesity has reached pandemic proportions and treatment is rarely successful for the long term. We believe that by elucidating the underlying physiology, novel and effective anti-obesity therapies will be discovered. Effective obesity treatment will also stem the epidemic of type 2 diabetes mellitus.
I am broadly interested in a mechanistic and translational understanding of diabetes, energy homeostasis, and obesity. My particular interests include studying mouse genetics and pharmacology, using mouse models to understand metabolic rate regulation, body temperature regulation and the role of BRS-3 (bombesin receptor subtype-3), and exploring drug treatments for obesity. One current project involves dissecting the neuroscience of how BRS-3 regulates metabolic rate, body temperature, and blood pressure. Another project explores how to improve the use of mice to evaluate candidate treatments for human obesity. A third interest is the role of brown adipose tissue and uncoupling in mouse and human thermal biology and body weight regulation.
Applying our Research
By studying the mechanisms involved in energy homeostasis, we should gain knowledge that will lead to advancements in the treatment of diabetes and obesity.
- Senior Investigator and Branch Chief, NIDDK, NIH, 2011-present
- Director, Clinical Research; Director Obesity and Metabolic Research, Merck Research Laboratories, 2002-2011
- Fellow; Investigator; Senior Investigator, NIDDK, NIH, 1986-2002
- Residency in Internal Medicine, Columbia-Presbyterian Hospital, 1983-1986
- M.D., Ph.D., Washington University, 1983
- B.S., Massachusetts Institute of Technology, 1977
Piñol RA, Zahler SH, Li C, Saha A, Tan BK, Škop V, Gavrilova O, Xiao C, Krashes MJ, Reitman ML. Brs3 neurons in the mouse dorsomedial hypothalamus regulate body temperature, energy expenditure, and heart rate, but not food intake. Nat Neurosci. 2018;21(11):1530-1540.
Xiao C, Piñol RA, Carlin JL, Li C, Deng C, Gavrilova O, Reitman ML. Bombesin-like receptor 3 (Brs3) expression in glutamatergic, but not GABAergic, neurons is required for regulation of energy metabolism. Mol Metab. 2017;6(11):1540-1550.
Carlin JL, Jain S, Gizewski E, Wan TC, Tosh DK, Xiao C, Auchampach JA, Jacobson KA, Gavrilova O, Reitman ML. Hypothermia in mouse is caused by adenosine A<sub>1</sub> and A<sub>3</sub> receptor agonists and AMP via three distinct mechanisms. Neuropharmacology. 2017;114:101-113.
Lateef DM, Xiao C, Brychta RJ, Diedrich A, Schnermann J, Reitman ML. Bombesin-like receptor 3 regulates blood pressure and heart rate via a central sympathetic mechanism. Am J Physiol Heart Circ Physiol. 2016;310(7):H891-8.
Abreu-Vieira G, Xiao C, Gavrilova O, Reitman ML. Integration of body temperature into the analysis of energy expenditure in the mouse. Mol Metab. 2015;4(6):461-70.
Related Scientific Focus Areas
Genetics and Genomics
Molecular Biology and Biochemistry
This page was last updated on October 29th, 2018