Lothar George Hennighausen, Ph.D.

Senior Investigator

Genetics and Physiology Section, Laboratory of Cell and Molecular Biology

NIDDK

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Building 8, Room 101
8 Center Dr
Bethesda, MD 20814

+1 301 328 6183

lotharh@mail.nih.gov

Research Topics

Our ultimate goal is to unlock the genetic logic that controls the mammary genome and leads to a functional mammary gland during pregnancy.

Biography

  • Sookmyung University, Brain Korea 21+, Visiting Professor (2018-present)
  • Student invited Seminar Speaker Series, Case Western Reserve University, Speaker (2018)
  • Mammary Gland Biology Gordon Conference, Keynote Speaker (2016)
  • Chonnam National University Medical School, Hwasun, Visiting Professor (2016-2018)
  • Annual Meeting, Cytokine Society, Plenary Speaker (2013)
  • Distinguished Lecture Series, Lady Davis Institute, McGill, Montreal, Speaker (2012)
  • Graduate Research Symposium, Memorial University, St. John’s, Canada, Keynote Speaker (2011)
  • Endocrine Society, Annual meeting, San Diego, Plenary Speaker (2010)
  • Korean Society for Molecular and Cellular Biology, Annual Meeting, Plenary Speaker, Seoul, Republic of Korea (2009)
  • Member and Chair (2009-2014), Scientific Advisory Board, Georg-Speyer Haus, Frankfurt, Germany (2009-present)
  • Chonnam National University, Gwangju, Visiting Professor (2008-2011)
  • Korean Society of Science and Engineering, Distinguished World Class Scholar (2008)
  • Deutsche Forschungsgemeinschaft, Mercator Professorship (2007)
  • Keystone Symposia, Whistler, Canada Plenary Speaker (2004)
  • Alexander von Humboldt Foundation, Humboldt Fellow (1992)
  • Selected, National Press Club, Mammary Gland Bioreactor, Washington D.C. (1987)
  • Deutsche Forschungsgemeinschaft, Post-Doctoral Fellowship (1983)
  • EMBO, Short-term Research Fellowship at Edinburgh University (1980)
  • Studienstiftung des Deutschen Volkes, Graduate Student Fellowship (1978)
  • Ph.D., University of Cologne, 1982
  • M.S., University of Cologne, 1979
  • B.S., Philipp University of Marburg, 1977

Selected Publications

  1. Yamaji D, Kang K, Robinson GW, Hennighausen L. Sequential activation of genetic programs in mouse mammary epithelium during pregnancy depends on STAT5A/B concentration. Nucleic Acids Res. 2013;41(3):1622-36.

  2. Shin HY, Wang C, Lee HK, Yoo KH, Zeng X, Kuhns T, Yang CM, Mohr T, Liu C, Hennighausen L. CRISPR/Cas9 targeting events cause complex deletions and insertions at 17 sites in the mouse genome. Nat Commun. 2017;8:15464.

  3. Metser G, Shin HY, Wang C, Yoo KH, Oh S, Villarino AV, O'Shea JJ, Kang K, Hennighausen L. An autoregulatory enhancer controls mammary-specific STAT5 functions. Nucleic Acids Res. 2016;44(3):1052-63.

  4. Shin HY, Willi M, HyunYoo K, Zeng X, Wang C, Metser G, Hennighausen L. Hierarchy within the mammary STAT5-driven Wap super-enhancer. Nat Genet. 2016;48(8):904-911.

  5. Yoo KH, Oh S, Kang K, Hensel T, Robinson GW, Hennighausen L. Loss of EZH2 results in precocious mammary gland development and activation of STAT5-dependent genes. Nucleic Acids Res. 2015;43(18):8774-89.

Related Scientific Focus Areas

This page was last updated on April 11th, 2019