Lothar George Hennighausen, Ph.D.

Senior Investigator

Genetics and Physiology Section, Laboratory of Cell & Molecular Biology

NIDDK

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Building NIHBC 08, Room 101
8 Center Dr
Bethesda, MD 20892

lotharh@mail.nih.gov

Research Topics

Our long-term goal is to unlock the genetic logic that controls the genome and to understand the impact of single nucleotide polymorphisms (SNPs) in the Janus Kinase-Signal Transducer and Activator of Transcription (JAK-STAT) pathway contributing to autoimmune disease to support design of therapeutic interventions.

Biography

  • Chief, Section of Genetics and Physiology, NIDDK, NIH
  • Principal Investigator, NIDDK, NIH (1985-present)
  • Post-doctoral fellow, Harvard Medical School (1983-1985)
  • Ph.D., University of Cologne, 1982
  • Diplom, University of Cologne, 1979
  • B.S., Philipp University of Marburg, 1977

Honors (selection)

  • Hans-Fischer Senior Fellow, Technical University Munich, Germany (2020)
  • NIH Director’s award for outstanding accomplishments (2019)
  • Keynote Speaker, FASEB Conference, Growth Hormone / Prolactin Family (2019)
  • Director’s Award, NIDDK/NIH (2017)
  • Orloff Award, NHLBI/NIH (2017)
  • Keynote Speaker, Mammary Gland Biology Gordon Conference, Keynote (2016)
  • Distinguished Lecture Series, Lady Davis Institute, McGill, Montreal (2012)
  • Keynote Speaker, Graduate Research Symposium, Memorial University, St. John’s, Canada (2011)
  • Plenary Speaker, Korean Society for Molecular and Cellular Biology, Seoul (2009)
  • Member and Chair, Scientific Advisory Board, Georg-Speyer Haus, Frankfurt, Germany (2009-2017)
  • Distinguished World Class Scholar, Korean Society of Science and Engineering (2008)
  • Mercator Professorship, Deutsche Forschungsgemeinschaft (2007)
  • Olof Pearson Award, Case Western Reserve University, Cleveland (2003)
  • Humboldt Research Award, Alexander von Humboldt Foundation (2002)
  • Humboldt Fellow, Alexander von Humboldt Foundation (1992)
  • Speaker, National Press Club, Washington D.C. (1987)

Selected Publications

  2. Lee HK, Knabl L, Moliva JI, Knabl L Sr, Werner AP, Boyoglu-Barnum S, Kapferer S, Pateter B, Walter M, Sullivan NJ, Furth PA, Hennighausen L. mRNA vaccination in octogenarians 15 and 20 months after recovery from COVID-19 elicits robust immune and antibody responses that include Omicron. Cell Rep. 2022;39(2):110680.
  3. Lee HK, Willi M, Miller SM, Kim S, Liu C, Liu DR, Hennighausen L. Targeting fidelity of adenine and cytosine base editors in mouse embryos. Nat Commun. 2018;9(1):4804.
  4. Shin HY, Wang C, Lee HK, Yoo KH, Zeng X, Kuhns T, Yang CM, Mohr T, Liu C, Hennighausen L. CRISPR/Cas9 targeting events cause complex deletions and insertions at 17 sites in the mouse genome. Nat Commun. 2017;8:15464.
  5. Shin HY, Willi M, HyunYoo K, Zeng X, Wang C, Metser G, Hennighausen L. Hierarchy within the mammary STAT5-driven Wap super-enhancer. Nat Genet. 2016;48(8):904-911.

Related Scientific Focus Areas

This page was last updated on Monday, April 21, 2025