
Lothar George Hennighausen, Ph.D.
Senior Investigator
Genetics and Physiology Section, Laboratory of Cell and Molecular Biology
NIDDK
Research Topics
Our ultimate goal is to unlock the genetic logic that controls the mammary genome and leads to a functional mammary gland during pregnancy.
Biography
- Sookmyung University, Brain Korea 21+, Visiting Professor (2018-present)
- Student invited Seminar Speaker Series, Case Western Reserve University, Speaker (2018)
- Mammary Gland Biology Gordon Conference, Keynote Speaker (2016)
- Chonnam National University Medical School, Hwasun, Visiting Professor (2016-2018)
- Annual Meeting, Cytokine Society, Plenary Speaker (2013)
- Distinguished Lecture Series, Lady Davis Institute, McGill, Montreal, Speaker (2012)
- Graduate Research Symposium, Memorial University, St. John’s, Canada, Keynote Speaker (2011)
- Endocrine Society, Annual meeting, San Diego, Plenary Speaker (2010)
- Korean Society for Molecular and Cellular Biology, Annual Meeting, Plenary Speaker, Seoul, Republic of Korea (2009)
- Member and Chair (2009-2014), Scientific Advisory Board, Georg-Speyer Haus, Frankfurt, Germany (2009-present)
- Chonnam National University, Gwangju, Visiting Professor (2008-2011)
- Korean Society of Science and Engineering, Distinguished World Class Scholar (2008)
- Deutsche Forschungsgemeinschaft, Mercator Professorship (2007)
- Keystone Symposia, Whistler, Canada Plenary Speaker (2004)
- Alexander von Humboldt Foundation, Humboldt Fellow (1992)
- Selected, National Press Club, Mammary Gland Bioreactor, Washington D.C. (1987)
- Deutsche Forschungsgemeinschaft, Post-Doctoral Fellowship (1983)
- EMBO, Short-term Research Fellowship at Edinburgh University (1980)
- Studienstiftung des Deutschen Volkes, Graduate Student Fellowship (1978)
- Ph.D., University of Cologne, 1982
- M.S., University of Cologne, 1979
- B.S., Philipp University of Marburg, 1977
Selected Publications
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Shin HY, Wang C, Lee HK, Yoo KH, Zeng X, Kuhns T, Yang CM, Mohr T, Liu C, Hennighausen L. CRISPR/Cas9 targeting events cause complex deletions and insertions at 17 sites in the mouse genome. Nat Commun. 2017;8:15464.
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Lee HK, Willi M, Miller SM, Kim S, Liu C, Liu DR, Hennighausen L. Targeting fidelity of adenine and cytosine base editors in mouse embryos. Nat Commun. 2018;9(1):4804.
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Lee HK, Smith HE, Liu C, Willi M, Hennighausen L. Cytosine base editor 4 but not adenine base editor generates off-target mutations in mouse embryos. Commun Biol. 2020;3(1):19.
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Shin HY, Willi M, HyunYoo K, Zeng X, Wang C, Metser G, Hennighausen L. Hierarchy within the mammary STAT5-driven Wap super-enhancer. Nat Genet. 2016;48(8):904-911.
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Willi M, Smith HE, Wang C, Liu C, Hennighausen L. Mutation frequency is not increased in CRISPR-Cas9-edited mice. Nat Methods. 2018;15(10):756-758.
Related Scientific Focus Areas
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Molecular Biology and Biochemistry
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This page was last updated on February 9th, 2021